Literature summary extracted from

Kwak, S.Y.; Yamakoshi, Y.; Simmer, J.P.; Margolis, H.C.
MMP20 Proteolysis of native amelogenin regulates mineralization in vitro (2016), J. Dent. Res., 95, 1511-1517 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B6	Sus scrofa	P79287	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.24.B6	-	Sus scrofa

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.B6	amelogenin + H2O	-	Sus scrofa	amelogenin fragment P148	-	?
3.4.24.B6	additional information	in vitro, the formation of well-aligned bundles of enamel-like hydroxyapatite crystals is promoted in the presence of amelogenin (P173) with added MMP20, while only amorphous calcium phosphate particles are seen in the absence of MMP20. Fragment P148 has a somewhat lower capacity to stabilize amorphous calcium phosphate and prevents hydroxyapatite formation compared with P173 in the absence of MMP20, and essentially no hydroxyapatite formation is observed in the presence of somewhat higher concentrations of P148 regardless of MMP20 addition. MMP20 does not cleave fragment P148	Sus scrofa	?	-	?

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Release 2023.1 (January 2023)