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Literature summary extracted from
- Understanding lipopolysaccharide aggregation and its influence on activation of Factor C (2019), J. Colloid Interface Sci., 552, 540-553 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.84 | lipopolysaccharide | Escherichia coli serotype O55:B5 lipopolysaccharide (LPS) is used with a potency of 10 EU/ng, structure analysis, reconstitution of lyophilized LPS into solution. Factor C is activated through lipopolysaccharide. The state of aggregation of LPS impacts factor C activation, particularly in the presence of select salts and non-ionic surfactants that are commonly incorporated into pharmaceutical formulations. Analysis of aggregation status of LPS in aqueous solution using angle-dependent static and dynamic light scattering with and without chelating salts and polysorbate surfactants, and its correlation with activation of factor C, overview. Modulating effects of salts and surfactants on activation of factor C is associated with changes in the LPS aggregation | Limulus polyphemus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.84 | pro-factor B + H2O | Limulus polyphemus | activation | factor B + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.84 | Limulus polyphemus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.84 | amoebocyte | - |
Limulus polyphemus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.84 | pro-factor B + H2O | activation | Limulus polyphemus | factor B + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.84 | Factor C | - |
Limulus polyphemus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.84 | metabolism | factor C is involved in the LPS reactive coagulation cascade system in the Limulus horseshoe crab that results in the formation of a coagulin gel | Limulus polyphemus |
| 3.4.21.84 | physiological function | Factor C activates factor B in the clotting cascade in Limulus polyphemus | Limulus polyphemus |
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