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Literature summary extracted from

  • Overland, A.C.; Insel, P.A.
    Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease. A novel mechanism for GPCR-EGFR transactivation (2015), J. Biol. Chem., 290, 9941-9947 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.80 angiotensin II
-
Rattus norvegicus
3.4.24.80 angiotensin II
-
Mus musculus
3.4.24.80 G protein MMP14 is directly activated by G protein betagamma subunits in a membrane-delimited manner, mechanism, overview Mus musculus
3.4.24.80 G protein MMP14 is directly activated by G protein betagamma subunits in a membrane-delimited manner, mechanism, overview. Gallein inhibits stimulation of MMP14 activity by GTPgammaS in cardiac myocyte membranes Rattus norvegicus
3.4.24.80 GTP
-
Rattus norvegicus
3.4.24.80 GTP
-
Mus musculus
3.4.24.80 guanosine 5'-O-[gamma-thio]triphosphate GTPgammaS Rattus norvegicus
3.4.24.80 guanosine 5'-O-[gamma-thio]triphosphate GTPgammaS Mus musculus
3.4.24.80 additional information MT1-MMP activation does not occur in response to GMP or adenosine 5'-[gamma-thio]triphosphate (ATPgammaS). The activation is specific to MMP14 as it is inhibited by a specific MMP14 peptide inhibitor and siRNA knockdown. MMP14 activation by GTPgammaS is pertussis toxin-sensitive Rattus norvegicus
3.4.24.80 additional information MT1-MMP activation does not occur in response to GMP or adenosine 5'-[gamma-thio]triphosphate (ATPgammaS). The activation is specific to MMP14 as it is inhibited by a specific MMP14 peptide inhibitor and siRNA knockdown. MMP14 activation by GTPgammaS is pertussis toxin-sensitive Mus musculus
3.4.24.80 phenylephrine
-
Rattus norvegicus
3.4.24.80 phenylephrine
-
Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.80 additional information siRNA-mediated knockout of MMP14 in NIH3T3 cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.80 plasma membrane
-
Rattus norvegicus 5886
-
3.4.24.80 plasma membrane
-
Mus musculus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.80 Zn2+ a zinc-dependent endopeptidase Rattus norvegicus
3.4.24.80 Zn2+ a zinc-dependent endopeptidase Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Mus musculus P53690
-
-
3.4.24.80 Rattus norvegicus Q10739
-
-
3.4.24.80 Rattus norvegicus Sprague-Dawley Q10739
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.80 proteolytic modification guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 Rattus norvegicus
3.4.24.80 proteolytic modification guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 cardiofibroblast
-
Rattus norvegicus
-
3.4.24.80 cardiomyocyte
-
Rattus norvegicus
-
3.4.24.80 NIH-3T3 cell
-
Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 membrane type-1 matrix metalloprotease
-
Rattus norvegicus
3.4.24.80 membrane type-1 matrix metalloprotease
-
Mus musculus
3.4.24.80 MMP14
-
Rattus norvegicus
3.4.24.80 MMP14
-
Mus musculus
3.4.24.80 MT1-MMP
-
Rattus norvegicus
3.4.24.80 MT1-MMP
-
Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.80 37
-
assay at Rattus norvegicus
3.4.24.80 37
-
assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.4.24.80 physiological function heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGF receptor transactivation. Analysis of the membrane-delimited mechanism for EGF receptor transactivation. MMP14 is a heterotrimeric G protein-regulated effector Rattus norvegicus
3.4.24.80 physiological function heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGF receptor transactivation. Analysis of the membrane-delimited mechanism for EGFreceptor transactivation. MMP14 is a heterotrimeric G protein-regulated effector Mus musculus