EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.80 | angiotensin II | - |
Rattus norvegicus | |
3.4.24.80 | angiotensin II | - |
Mus musculus | |
3.4.24.80 | G protein | MMP14 is directly activated by G protein betagamma subunits in a membrane-delimited manner, mechanism, overview | Mus musculus | |
3.4.24.80 | G protein | MMP14 is directly activated by G protein betagamma subunits in a membrane-delimited manner, mechanism, overview. Gallein inhibits stimulation of MMP14 activity by GTPgammaS in cardiac myocyte membranes | Rattus norvegicus | |
3.4.24.80 | GTP | - |
Rattus norvegicus | |
3.4.24.80 | GTP | - |
Mus musculus | |
3.4.24.80 | guanosine 5'-O-[gamma-thio]triphosphate | GTPgammaS | Rattus norvegicus | |
3.4.24.80 | guanosine 5'-O-[gamma-thio]triphosphate | GTPgammaS | Mus musculus | |
3.4.24.80 | additional information | MT1-MMP activation does not occur in response to GMP or adenosine 5'-[gamma-thio]triphosphate (ATPgammaS). The activation is specific to MMP14 as it is inhibited by a specific MMP14 peptide inhibitor and siRNA knockdown. MMP14 activation by GTPgammaS is pertussis toxin-sensitive | Rattus norvegicus | |
3.4.24.80 | additional information | MT1-MMP activation does not occur in response to GMP or adenosine 5'-[gamma-thio]triphosphate (ATPgammaS). The activation is specific to MMP14 as it is inhibited by a specific MMP14 peptide inhibitor and siRNA knockdown. MMP14 activation by GTPgammaS is pertussis toxin-sensitive | Mus musculus | |
3.4.24.80 | phenylephrine | - |
Rattus norvegicus | |
3.4.24.80 | phenylephrine | - |
Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.24.80 | additional information | siRNA-mediated knockout of MMP14 in NIH3T3 cells | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.80 | plasma membrane | - |
Rattus norvegicus | 5886 | - |
3.4.24.80 | plasma membrane | - |
Mus musculus | 5886 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.80 | Zn2+ | a zinc-dependent endopeptidase | Rattus norvegicus | |
3.4.24.80 | Zn2+ | a zinc-dependent endopeptidase | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.80 | Mus musculus | P53690 | - |
- |
3.4.24.80 | Rattus norvegicus | Q10739 | - |
- |
3.4.24.80 | Rattus norvegicus Sprague-Dawley | Q10739 | - |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.80 | proteolytic modification | guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 | Rattus norvegicus |
3.4.24.80 | proteolytic modification | guanosine 5'-O-[gamma-thio]triphosphate (GTPgammaS)-stimulated activation of MMP14 | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.80 | cardiofibroblast | - |
Rattus norvegicus | - |
3.4.24.80 | cardiomyocyte | - |
Rattus norvegicus | - |
3.4.24.80 | NIH-3T3 cell | - |
Mus musculus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.80 | membrane type-1 matrix metalloprotease | - |
Rattus norvegicus |
3.4.24.80 | membrane type-1 matrix metalloprotease | - |
Mus musculus |
3.4.24.80 | MMP14 | - |
Rattus norvegicus |
3.4.24.80 | MMP14 | - |
Mus musculus |
3.4.24.80 | MT1-MMP | - |
Rattus norvegicus |
3.4.24.80 | MT1-MMP | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.24.80 | 37 | - |
assay at | Rattus norvegicus |
3.4.24.80 | 37 | - |
assay at | Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.24.80 | physiological function | heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGF receptor transactivation. Analysis of the membrane-delimited mechanism for EGF receptor transactivation. MMP14 is a heterotrimeric G protein-regulated effector | Rattus norvegicus |
3.4.24.80 | physiological function | heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGF receptor transactivation. Analysis of the membrane-delimited mechanism for EGFreceptor transactivation. MMP14 is a heterotrimeric G protein-regulated effector | Mus musculus |