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Literature summary extracted from

  • Kremer, L.; Douglas, J.D.; Baulard, A.R.; Morehouse, C.; Guy, M.R.; Alland, D.; Dover, L.G.; Lakey, J.H.; Jacobs, W.R.; Brennan, P.J.; Minnikin, D.E.; Besra, G.S.
    Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis (2000), J. Biol. Chem., 275, 16857-16864 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.293 expressed in Mycobacterium bovis BCG vaccine strain 1173P2 Mycobacterium tuberculosis
2.3.1.294 expressed in Mycobacterium bovis BCG vaccine strain 1173P2 Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.293 G269S the S mutation may affect targeting of the inhibitor thiolactomycin to the enzyme Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.293 thiolactomycin
-
 Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.293 cytosol
-
 Mycobacterium tuberculosis 5829
-
2.3.1.294 cytosol
-
 Mycobacterium tuberculosis 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.293 additional information Mycobacterium tuberculosis the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids ?
-
 ?
2.3.1.293 additional information Mycobacterium tuberculosis H37Rv the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.293 Mycobacterium tuberculosis
-
-
-
2.3.1.293 Mycobacterium tuberculosis H37Rv
-
-
-
2.3.1.294 Mycobacterium tuberculosis
-
-
-
2.3.1.294 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.293 additional information the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids Mycobacterium tuberculosis ?
-
 ?
2.3.1.293 additional information the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.293 ? x * 43000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.3.1.293 beta-ketoacyl-acyl-carrier protein synthase
-
 Mycobacterium tuberculosis
2.3.1.293 KasA
-
 Mycobacterium tuberculosis
2.3.1.293 Rv2245
-
 Mycobacterium tuberculosis
2.3.1.294 beta-ketoacyl-acyl-carrier protein synthase
-
 Mycobacterium tuberculosis
2.3.1.294 KasB
-
 Mycobacterium tuberculosis
2.3.1.294 Rv2246
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.293 metabolism the enzyme is involved in fatty acid and mycolic acid biosynthesis Mycobacterium tuberculosis
2.3.1.294 metabolism the enzyme is involved in fatty acid and mycolic acid biosynthesis Mycobacterium tuberculosis