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Literature summary extracted from

  • Hachisuka, S.I.; Sato, T.; Atomi, H.
    Hyperthermophilic archaeon Thermococcus kodakarensis utilizes a four-step pathway for NAD+ salvage through nicotinamide deamination (2018), J. Bacteriol., 200, e00785-17 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1 expression in Escherichia coli Thermococcus kodakarensis
3.5.1.42 gene TK1650, recombinant expression in Thermococcus kodakarensis strain KU216 Thermococcus kodakarensis

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.42 additional information construction of a TK1650 knockout mutant strain Thermococcus kodakarensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide mononucleotide Thermococcus kodakarensis
-
 diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide mononucleotide Thermococcus kodakarensis ATCC BAA-918
-
 diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinic acid mononucleotide Thermococcus kodakarensis
-
 diphosphate + deamido-NAD+
-
 ?
2.7.7.1 ATP + nicotinic acid mononucleotide Thermococcus kodakarensis ATCC BAA-918
-
 diphosphate + deamido-NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Thermococcus kodakarensis Q5JEF8
-
-
2.7.7.1 Thermococcus kodakarensis ATCC BAA-918 Q5JEF8
-
-
3.5.1.42 Thermococcus kodakarensis Q5JIT6 i.e. Pyrococcus kodakaraensis strain KOD1
-
3.5.1.42 Thermococcus kodakarensis ATCC BAA-918 Q5JIT6 i.e. Pyrococcus kodakaraensis strain KOD1
-
3.5.1.42 Thermococcus kodakarensis JCM 12380 Q5JIT6 i.e. Pyrococcus kodakaraensis strain KOD1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide mononucleotide
-
 Thermococcus kodakarensis diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide mononucleotide
-
 Thermococcus kodakarensis ATCC BAA-918 diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinic acid mononucleotide
-
 Thermococcus kodakarensis diphosphate + deamido-NAD+
-
 ?
2.7.7.1 ATP + nicotinic acid mononucleotide
-
 Thermococcus kodakarensis ATCC BAA-918 diphosphate + deamido-NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 TK0067
-
 Thermococcus kodakarensis
3.5.1.42 Nm deamidase
-
 Thermococcus kodakarensis
3.5.1.42 TK1650
-
 Thermococcus kodakarensis

General Information

EC Number General Information Comment Organism
2.7.7.1 physiological function the enzyme is involved in the salvage pathways for NAD+ biosynthesis Thermococcus kodakarensis
3.5.1.42 metabolism the hyperthermophilic archaeon Thermococcus kodakarensis utilizes a four-step pathway for NAD+ salvage through nicotinamide deamination Thermococcus kodakarensis