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Literature summary extracted from

  • Ohnuki, T.; Yano, T.; Ono, Y.; Kozuma, S.; Suzuki, T.; Ogawa, Y.; Takatsu, T.
    Haplofungins, novel inositol phosphorylceramide synthase inhibitors, from Lauriomyces bellulus SANK 26899 I. Taxonomy, fermentation, isolation and biological activities (2009), J. Antibiot., 62, 545-549 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.227 haplofungin A isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.25 microg/ml and suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml Aspergillus fumigatus
2.7.1.227 haplofungin A isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.0015 microg/ml and also suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml Saccharomyces cerevisiae
2.7.1.227 haplofungin E isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.24 microg/ml and suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml Aspergillus fumigatus
2.7.1.227 haplofungin E isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.0015 microg/ml and also suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.227 Aspergillus fumigatus
-
-
-
2.7.1.227 Saccharomyces cerevisiae
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.227 IPC synthase
-
 Saccharomyces cerevisiae
2.7.1.227 IPC synthase
-
 Aspergillus fumigatus