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Literature summary extracted from

  • Jayaraman, M.; Rajendra, S.; Ramadas, K.
    Structural insight into conformational dynamics of non-active site mutations in KasA A Mycobacterium tuberculosis target protein (2019), Gene, 720, 144082 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.41 D66N the non-active site mutation alters the structural stability of the mutant protein structures Mycobacterium tuberculosis
2.3.1.41 F413L the non-active site mutation alters the structural stability of the mutant protein structures Mycobacterium tuberculosis
2.3.1.41 G269S the non-active site mutation alters the structural stability of the mutant protein structures Mycobacterium tuberculosis
2.3.1.41 G312S the non-active site mutation alters the structural stability of the mutant protein structures Mycobacterium tuberculosis
2.3.1.293 D66N dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis
2.3.1.293 F413L dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis
2.3.1.293 G269S dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis
2.3.1.293 G312S dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.41 an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.41 an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.293 an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.293 an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.41 Mycobacterium tuberculosis P9WQD9
-
-
2.3.1.41 Mycobacterium tuberculosis H37Rv P9WQD9
-
-
2.3.1.293 Mycobacterium tuberculosis P9WQD9 cf. EC 2.3.1.41
-
2.3.1.293 Mycobacterium tuberculosis H37Rv P9WQD9 cf. EC 2.3.1.41
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.41 an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.41 an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.293 an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
2.3.1.293 an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.41 beta-ketoacyl ACP synthase I
-
 Mycobacterium tuberculosis
2.3.1.41 Kas A
-
 Mycobacterium tuberculosis
2.3.1.293 beta-ketoacyl ACP synthase I
-
 Mycobacterium tuberculosis
2.3.1.293 KasA
-
 Mycobacterium tuberculosis