Literature summary extracted from

Shelar, S.; Shim, E.H.; Brinkley, G.J.; Kundu, A.; Carobbio, F.; Poston, T.; Tan, J.; Parekh, V.; Benson, D.; Crossman, D.K.; Buckhaults, P.J.; Rakheja, D.; Kirkman, R.; Sato, Y.; Ogawa, S.; Dutta, S.; Velu, S.E.; Emberley, E.; Pan, A.; Chen, J.; Huang, T.; Absher, D.; Becker, A.; Kunick, C.; Sudarshan, S.
Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer (2018), Clin. Cancer Res., 24, 6433-6446 .

Application

EC Number	Application	Comment	Organism
1.1.5.13	medicine	lower enzyme expression is associated with tumor progression and/or worsened prognosis in patients with renal cell carcinoma	Homo sapiens

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.5.13	L-2-hydroxyglutarate + a quinone	Homo sapiens	-	2-oxoglutarate + a quinol	-	?

EC Number	Organism	UniProt	Comment	Textmining
1.1.5.13	Homo sapiens	-	-	-

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.5.13	769-P cell	-	Homo sapiens	-
1.1.5.13	A-498 cell	-	Homo sapiens	-
1.1.5.13	A-498 cell	mutation A241G in A498 cells	Homo sapiens	-
1.1.5.13	Caki-1 cell	-	Homo sapiens	-
1.1.5.13	OS-RC-2 cell	-	Homo sapiens	-
1.1.5.13	renal cell carcinoma cell	-	Homo sapiens	-
1.1.5.13	RXF-393 cell	-	Homo sapiens	-

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.5.13	L-2-hydroxyglutarate + a quinone	-	Homo sapiens	2-oxoglutarate + a quinol	-	?

EC Number	Synonyms	Comment	Organism
1.1.5.13	L-2-HG dehydrogenase	-	Homo sapiens
1.1.5.13	L-2-hydroxyglutarate dehydrogenase	-	Homo sapiens
1.1.5.13	L2HGDH	-	Homo sapiens

EC Number	General Information	Comment	Organism
1.1.5.13	physiological function	the enzyme suppresses both in vitro cell migration and in vivo tumor growth in renal cell carcinoma	Homo sapiens