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Literature summary extracted from

  • Kim, H.J.; Lee, K.Y.; Kwon, A.R.; Lee, B.J.
    Structural and functional studies of SAV0551 from Staphylococcus aureus as a chaperone and glyoxalase III (2017), Biosci. Rep., 37, BSR20171106 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.130 hanging-drop vapor diffusion method at 20°C, the crystal structure of SAV0551 was determined at 2.6 A resolution including the additional C-terminal histidine tag Staphylococcus aureus

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.130 C190A diminished glyoxalase III activity Staphylococcus aureus
4.2.1.130 E81A diminished glyoxalase III activity Staphylococcus aureus
4.2.1.130 H191A marginal glyoxalase III activity Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.130 methylglyoxal + H2O Staphylococcus aureus
-
 (R)-lactate
-
 ?
4.2.1.130 methylglyoxal + H2O Staphylococcus aureus ATCC 700699
-
 (R)-lactate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.130 Staphylococcus aureus P64312
-
-
4.2.1.130 Staphylococcus aureus ATCC 700699 P64312
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.130 methylglyoxal + H2O
-
 Staphylococcus aureus (R)-lactate
-
 ?
4.2.1.130 methylglyoxal + H2O
-
 Staphylococcus aureus ATCC 700699 (R)-lactate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.130 glyoxalase III
-
 Staphylococcus aureus
4.2.1.130 SAV0551
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.130 additional information glyoxalase III does not require any cofactors Staphylococcus aureus