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Literature summary extracted from

  • Rehman, N.U.; Khan, A.; Al-Harrasi, A.; Khiat, M.; Hussain, H.; Wadood, A.; Riaz, M.
    Natural urease inhibitors from Aloe vera resin and Lycium shawii and their structural-activity relationship and molecular docking study (2019), Bioorg. Chem., 88, 102955 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 (+)-costunolide 0.5 mM, 30°C, pH 6.8, 56.5% inhibition Canavalia ensiformis
3.5.1.5 (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol 0.5 mM, 30°C, pH 6.8, 81.5% inhibition Canavalia ensiformis
3.5.1.5 10-hydroxyaloin A 0.5 mM, 30°C, pH 6.8, 46.9% inhibition Canavalia ensiformis
3.5.1.5 4-(methoxymethyl)-5-methylbenzene-1,3-diol 0.5 mM, 30°C, pH 6.8, 91.5% inhibition Canavalia ensiformis
3.5.1.5 6'-O-coumaroylaloesin 0.5 mM, 30°C, pH 6.8, 91.3% inhibition Canavalia ensiformis
3.5.1.5 7-hydroxy-4-methoxy-5-methyl-2H-1-benzopyran-2-one
-
 Canavalia ensiformis
3.5.1.5 7-methoxy-6'-O-coumaroylaloesin 0.5 mM, 30°C, pH 6.8, 93.5% inhibition Canavalia ensiformis
3.5.1.5 aloe emodin 0.5 mM, 30°C, pH 6.8, 83.5% inhibition Canavalia ensiformis
3.5.1.5 aloe emodin 11-O-alpha-D-rhamnopyranoside 0.5 mM, 30°C, pH 6.8, 53.6% inhibition Canavalia ensiformis
3.5.1.5 aloinoside B 0.5 mM, 30°C, pH 6.8, 45.7% inhibition Canavalia ensiformis
3.5.1.5 emodin 0.5 mM, 30°C, pH 6.8, 46.9% inhibition Canavalia ensiformis
3.5.1.5 feralolide 0.5 mM, 30°C, pH 6.8, 88.7% inhibition Canavalia ensiformis
3.5.1.5 feroxidin 0.5 mM, 30°C, pH 6.8, 91.3% inhibition Canavalia ensiformis
3.5.1.5 lyciumaside 0.5 mM, 30°C, pH 6.8, 83.5% inhibition Canavalia ensiformis
3.5.1.5 additional information natural urease inhibitors from Aloe vera resin and Lycium shawii are isolated from the methanol extracts Canavalia ensiformis
3.5.1.5 Thiourea 0.5 mM, 30°C, pH 6.8, 98.0% inhibition Canavalia ensiformis

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Canavalia ensiformis P07374
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.5 urea + H2O
-
 Canavalia ensiformis CO2 + 2 NH3
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.5 0.014
-
 30°C, pH 6.8 Canavalia ensiformis lyciumaside
3.5.1.5 0.0145
-
 30°C, pH 6.8 Canavalia ensiformis feralolide
3.5.1.5 0.0167
-
 30°C, pH 6.8 Canavalia ensiformis 4-(methoxymethyl)-5-methylbenzene-1,3-diol
3.5.1.5 0.021
-
 30°C, pH 7.8 Canavalia ensiformis Thiourea
3.5.1.5 0.0256
-
 30°C, pH 6.8 Canavalia ensiformis 6'-O-coumaroylaloesin
3.5.1.5 0.0368
-
 30°C, pH 6.8 Canavalia ensiformis (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
3.5.1.5 0.0373
-
 30°C, pH 6.8 Canavalia ensiformis 7-methoxy-6'-O-coumaroylaloesin
3.5.1.5 0.0393
-
 30°C, pH 6.8 Canavalia ensiformis feroxidin
3.5.1.5 0.1149
-
 30°C, pH 6.8 Canavalia ensiformis aloe emodin
3.5.1.5 0.4164
-
 30°C, pH 6.8 Canavalia ensiformis aloe emodin 11-O-alpha-D-rhamnopyranoside
3.5.1.5 0.4351
-
 30°C, pH 6.8 Canavalia ensiformis (+)-costunolide