Literature summary extracted from
Arafet, K.; Ferrer, S.; Moliner, V.
First quantum mechanics/molecular mechanics studies of the inhibition mechanism of cruzain by peptidyl halomethyl ketones (2015), Biochemistry, 54, 3381-3391 .
Application
EC Number |
Application |
Comment |
Organism |
---|
3.4.22.51 |
medicine |
cruzain is a primary cysteine protease expressed by the protozoan parasite Trypanosoma cruzi during Chagas disease infection, and thus, the development of inhibitors of this protein is a promising target for designing an effective therapy against the disease |
Trypanosoma cruzi |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.4.22.51 |
benzoyl-Tyr-Ala-chloromethyl ketone |
first quantum mechanics/molecular mechanics studies show that benzoyl-Tyr-Ala-chloromethyl ketone is a good candidate for the development of a proper inhibitor of cruzain, which in turn can be used in the treatment of Chagas desease |
Trypanosoma cruzi |
|
3.4.22.51 |
benzoyl-Tyr-Ala-fluoromethyl ketone |
- |
Trypanosoma cruzi |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.22.51 |
Trypanosoma cruzi |
P25779 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
3.4.22.51 |
cruzain |
- |
Trypanosoma cruzi |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
3.4.22.51 |
metabolism |
the enzyme is expressed by the protozoan parasite Trypanosoma cruzi during Chagas disease infection |
Trypanosoma cruzi |