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Literature summary extracted from

  • Allen, K.; Miller, D.; Rauch, B.; Perona, J.; White, R.
    Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea (2015), Biochemistry, 54, 3129-3132 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ Methanocaldococcus jannaschii
-
 L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ Methanosarcina acetivorans
-
 L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ Methanosarcina acetivorans DSM 2834
-
 L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ Methanocaldococcus jannaschii ATCC 43067
-
 L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.16 Methanocaldococcus jannaschii Q57564
-
-
2.8.1.16 Methanocaldococcus jannaschii ATCC 43067 Q57564
-
-
2.8.1.16 Methanosarcina acetivorans Q8TPT4
-
-
2.8.1.16 Methanosarcina acetivorans DSM 2834 Q8TPT4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
-
 Methanocaldococcus jannaschii L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
-
 Methanosarcina acetivorans L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
-
 Methanosarcina acetivorans DSM 2834 L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?
2.8.1.16 hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
-
 Methanocaldococcus jannaschii ATCC 43067 L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.16 MA1821
-
 Methanosarcina acetivorans
2.8.1.16 MA_1821
-
 Methanosarcina acetivorans
2.8.1.16 MJ0100
-
 Methanocaldococcus jannaschii