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Literature summary extracted from

  • Barbosa da Silva, E.; Dall, E.; Briza, P.; Brandstetter, H.; Ferreira, R.S.
    Cruzain structures apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design (2019), Acta Crystallogr. Sect. F, 75, 419-427 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.51
-
 Trypanosoma cruzi

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.22.51 cruzain crystals diffract to 1.2 A resolution, yielding two novel cruzain structures: apocruzain and cruzain bound to the reversible covalent inhibitor S-methyl thiomethanesulfonate. Mass-spectrometric experiments confirm the presence of a methylthiol group attached to the catalytic cysteine Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.51 S-methyl thiomethanesulfonate
-
 Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.51 Trypanosoma cruzi P25779
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.51
-
 Trypanosoma cruzi

General Information

EC Number General Information Comment Organism
3.4.22.51 physiological function cruzain is the major cysteine protease involved in the survival of the parasite Trypanosoma cruzi Trypanosoma cruzi