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Literature summary extracted from
- Development of an inhibitor screening assay for mono-ADP-ribosyl hydrolyzing macrodomains using AlphaScreen technology (2018), SLAS Discov., 23, 255-263 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.106 | expressed in Escherichia coli Rosetta 2 (DE3) cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.106 | ADP-D-ribose | - |
Homo sapiens |  |
| 3.1.1.106 | Ethacrynic acid | - |
Homo sapiens | |
| 3.1.1.106 | patulin | most potent inhibitor | Homo sapiens | |
| 3.1.1.106 | thimerosal | - |
Homo sapiens | |
| 3.1.1.106 | triclosan | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | Homo sapiens | - |
ADP-D-ribose + acetate | - |
? | |
| 3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | Homo sapiens | - |
ADP-D-ribose + acetate | - |
? | |
| 3.1.1.106 | [SRPK2 protein]-ADP-D-ribose + H2O | Homo sapiens | - |
[SRPK2 protein] + ADP-D-ribose | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.106 | Homo sapiens | Q9BQ69 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.106 | HisTrap column chromatography and Superdex 75 gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? | |
| 3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? | |
| 3.1.1.106 | [SRPK2 protein]-ADP-D-ribose + H2O | - |
Homo sapiens | [SRPK2 protein] + ADP-D-ribose | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.106 | MACROD1 | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.106 | 0.0025 | - |
at pH 7.5 and 25°C | Homo sapiens | patulin | |
| 3.1.1.106 | 0.0052 | - |
at pH 7.5 and 25°C | Homo sapiens | thimerosal | |
| 3.1.1.106 | 0.027 | - |
at pH 7.5 and 25°C | Homo sapiens | Ethacrynic acid | |
| 3.1.1.106 | 0.1 | - |
at pH 7.5 and 25°C | Homo sapiens | triclosan | |
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Release 2023.1 (January 2023)
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