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Literature summary extracted from

  • Ono, T.; Kasamatsu, A.; Oka, S.; Moss, J.
    The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases (2006), Proc. Natl. Acad. Sci. USA, 103, 16687-16691 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.106 additional information not affected by dithiothreitol Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.106 D77N/D78N hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations Homo sapiens
3.1.1.106 E238Q/E239Q the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose Homo sapiens
3.1.1.106 E261Q/E262Q the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.106 ADP-D-ribose competitive inhibitor Homo sapiens
3.1.1.106 additional information D-ribose 5-phosphate, AMP, ADP and beta-NAD have relatively little inhibitory effect on the enzyme activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.106 Mg2+ dependent on Mg2+. 1 mM is used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.106 O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 poly(ADP-D-ribose) + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.106 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.106 O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 poly(ADP-D-ribose) + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.106 ? x * 39000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.106 ARH3
-
 Homo sapiens
3.1.1.106 O-acetyl-ADP-ribose hydrolase
-
 Homo sapiens
3.1.1.106 poly(ADP-ribose) glycohydrolase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.106 0.002
-
 ADP-D-ribose at pH 7.0 and 30°C Homo sapiens