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Literature summary extracted from

  • Manikandan, K.; Sabareesh, V.; Singh, N.; Saigal, K.; Mechold, U.; Sinha, K.
    Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis (2014), PLoS ONE, 9, e86096 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.7 exprerssion in Escherichia coli Mycobacterium tuberculosis
3.1.4.59 expression in Escherichia coli Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.7 D130A/H131A mutant fails to hydrolyze c-di-AMP Mycobacterium tuberculosis
3.1.4.59 D130A/H131A mutant fails to hydrolyze c-di-AMP Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.7 soluble
-
Mycobacterium tuberculosis
-
-
3.1.4.59 soluble
-
Mycobacterium tuberculosis
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.7 Mycobacterium tuberculosis P71615 bifunctional oligoribonuclease and PAP phosphatase, enzyme has a DHH/DHHA1 domein
-
3.1.3.7 Mycobacterium tuberculosis H37Rv P71615 bifunctional oligoribonuclease and PAP phosphatase, enzyme has a DHH/DHHA1 domein
-
3.1.4.59 Mycobacterium tuberculosis P71615 bifunctional oligoribonuclease and PAP phosphatase, cf. EC 3.1.3.7. Enzyme has a DHH/DHHA1 domain
-
3.1.4.59 Mycobacterium tuberculosis H37Rv P71615 bifunctional oligoribonuclease and PAP phosphatase, cf. EC 3.1.3.7. Enzyme has a DHH/DHHA1 domain
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.7 adenosine 3',5'-bisphosphate + H2O
-
Mycobacterium tuberculosis AMP + phosphate
-
?
3.1.3.7 adenosine 3',5'-bisphosphate + H2O
-
Mycobacterium tuberculosis H37Rv AMP + phosphate
-
?
3.1.3.7 additional information enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60 Mycobacterium tuberculosis ?
-
?
3.1.3.7 additional information enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60 Mycobacterium tuberculosis H37Rv ?
-
?
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
Mycobacterium tuberculosis 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
?
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
Mycobacterium tuberculosis H37Rv 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
?
3.1.4.59 additional information enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60 Mycobacterium tuberculosis ?
-
?
3.1.4.59 additional information enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60 Mycobacterium tuberculosis H37Rv ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.7 NrnA
-
Mycobacterium tuberculosis
3.1.3.7 Rv2837c
-
Mycobacterium tuberculosis
3.1.4.59 NrnA
-
Mycobacterium tuberculosis
3.1.4.59 Rv2837c
-
Mycobacterium tuberculosis