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Literature summary extracted from

  • Jeankumar, V.U.; Reshma, R.S.; Janupally, R.; Saxena, S.; Sridevi, J.P.; Medapi, B.; Kulkarni, P.; Yogeeswari, P.; Sriram, D.
    Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain lead optimization and structure activity profiling (2015), Org. Biomol. Chem., 13, 2423-2431 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.2.2 expressed in Escherichia coli BL21 (DE3) pLysS cells Mycolicibacterium smegmatis
5.6.2.2 expressed in Escherichia coli BL21 (DE3) pLysS cells Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
5.6.2.2 4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
5.6.2.2 4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-4,5-dihydro-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
5.6.2.2 4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-4,5-dihydro-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
5.6.2.2 novobiocin
-
 Mycobacterium tuberculosis
5.6.2.2 novobiocin
-
 Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Mycobacterium tuberculosis
-
-
-
5.6.2.2 Mycobacterium tuberculosis H37Rv
-
-
-
5.6.2.2 Mycolicibacterium smegmatis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.2.2 Ni-NTA column chromatography Mycolicibacterium smegmatis
5.6.2.2 Ni-NTA column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 ATP + supercoiled pBR322 DNA
-
 Mycolicibacterium smegmatis ADP + phosphate + relaxed pBR322 DNA
-
 ?
5.6.2.2 ATP + supercoiled pBR322 DNA
-
 Mycobacterium tuberculosis ADP + phosphate + relaxed pBR322 DNA
-
 ?
5.6.2.2 ATP + supercoiled pBR322 DNA
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + relaxed pBR322 DNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA gyrase
-
 Mycolicibacterium smegmatis
5.6.2.2 DNA gyrase
-
 Mycobacterium tuberculosis
5.6.2.2 GyrB
-
 Mycolicibacterium smegmatis
5.6.2.2 GyrB
-
 Mycobacterium tuberculosis
5.6.2.2 type II topoisomerase
-
 Mycolicibacterium smegmatis
5.6.2.2 type II topoisomerase
-
 Mycobacterium tuberculosis