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Literature summary extracted from

  • Gokhale, R.; Saxena, P.; Chopra, T.; Mohanty, D.
    Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids (2007), Nat. Prod. Rep., 24, 267-277 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.287 7 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH + 14 H+ Mycobacterium tuberculosis
-
 7 CO2 + C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 14 NADP+ + 7 CoA + 7 H2O
-
 ?
2.3.1.287 8 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH + 16 H+ Mycobacterium tuberculosis
-
 8 CoA + C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 16 NADP+ + 8 CO2 + 8 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.287 Mycobacterium tuberculosis
-
-
-
6.2.1.57 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.287 7 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH + 14 H+
-
 Mycobacterium tuberculosis 7 CO2 + C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 14 NADP+ + 7 CoA + 7 H2O
-
 ?
2.3.1.287 8 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH + 16 H+
-
 Mycobacterium tuberculosis 8 CoA + C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 16 NADP+ + 8 CO2 + 8 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.287 Pks2
-
 Mycobacterium tuberculosis
2.3.1.287 polyketide synthase
-
 Mycobacterium tuberculosis
6.2.1.57 FAAL
-
 Mycobacterium tuberculosis
6.2.1.57 fadD23
-
 Mycobacterium tuberculosis
6.2.1.57 fatty acyl-AMP ligase
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.287 metabolism the enzyme is required for sulfolipid biosynthesis and synthesizes phthioceronic acids and hydroxyphthioceronic acids as the major components of mycobacterial sulfolipids Mycobacterium tuberculosis