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Literature summary extracted from

  • Trivedi, O.A.; Arora, P.; Vats, A.; Ansari, M.Z.; Tickoo, R.; Sridharan, V.; Mohanty, D.; Gokhale, R.S.
    Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid (2005), Mol. Cell, 17, 631-643 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.282 synthesis use of PapA5 and a mutant mycocerosic acid synthase for synthesis of nonmethylated variants of mycocerosate esters Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.282 homology modeling and docking of modeled mycocerosic acid synthase docked on the structure of PapA5 Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.282 0.024
-
 2-Dodecanol pH 7.0, 30°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol Mycobacterium tuberculosis
-
 a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol Mycobacterium tuberculosis H37Rv
-
 a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol Mycobacterium tuberculosis
-
 a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol Mycobacterium tuberculosis H37Rv
-
 a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone Mycobacterium tuberculosis
-
 a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone Mycobacterium tuberculosis H37Rv
-
 a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 additional information Mycobacterium tuberculosis PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate ?
-
 ?
2.3.1.282 additional information Mycobacterium tuberculosis H37Rv PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.282 Mycobacterium tuberculosis P9WIN5
-
-
2.3.1.282 Mycobacterium tuberculosis H37Rv P9WIN5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol
-
 Mycobacterium tuberculosis a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol
-
 Mycobacterium tuberculosis H37Rv a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol
-
 Mycobacterium tuberculosis a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol
-
 Mycobacterium tuberculosis H37Rv a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone
-
 Mycobacterium tuberculosis a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone
-
 Mycobacterium tuberculosis H37Rv a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 lauroyl-[mycocerosic acid synthase] + 2-dodecanol
-
 Mycobacterium tuberculosis 2-dodecanyl dodecanoate + holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 lauroyl-[mycocerosic acid synthase] + 2-dodecanol
-
 Mycobacterium tuberculosis H37Rv 2-dodecanyl dodecanoate + holo-[mycocerosic acid synthase]
-
 ?
2.3.1.282 additional information PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate Mycobacterium tuberculosis ?
-
 ?
2.3.1.282 additional information PapA5 protein directly transfers the protein bound mycocerosic acid analogs on phthiocerol to catalyze the final esterification step of phthiocerol dimycocerisate Mycobacterium tuberculosis H37Rv ?
-
 ?