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Literature summary extracted from

  • Avalos, J.L.; Boeke, J.D.; Wolberger, C.
    Structural basis for the mechanism and regulation of Sir2 enzymes (2004), Mol. Cell, 13, 639-648 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.286 expressed in Escherichia coli Archaeoglobus fulgidus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.286 enzyme in a productive complex with NAD+, in a nonproductive NAD+ complex and in the unliganded state, hanging drop vapor diffusion method, using 0.1 M HEPES (pH 7.4), 1.8 M ammonium sulfate, and 1% (w/v) PEG400 at 20°C Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Archaeoglobus fulgidus
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Archaeoglobus fulgidus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.286
-
 Archaeoglobus fulgidus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Archaeoglobus fulgidus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 Sir2Af2
-
 Archaeoglobus fulgidus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Archaeoglobus fulgidus