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Literature summary extracted from

  • Dileep, K.V.; Remya, C.; Cerezo, J.; Fassihi, A.; Perez-Sanchez, H.; Sadasivan, C.
    Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway (2015), Mol. Biosyst., 11, 1973-1979 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 aspirin
-
 Sus scrofa
3.1.1.4 gallic acid inhibitory in micromolar concentrations Sus scrofa
3.1.1.4 protocatechuic acid inhibitory in micromolar concentrations Sus scrofa
3.1.1.4 syringic acid inhibitory in micromolar concentrations Sus scrofa
3.1.1.4 vanillic acid inhibitory in micromolar concentrations Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Sus scrofa P00592
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 pancreas
-
 Sus scrofa
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 ppPLA2
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.4 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.4 8.5
-
 assay at Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.4 0.00095
-
 gallic acid pH 8.5, 37°C Sus scrofa
3.1.1.4 0.00129
-
 protocatechuic acid pH 8.5, 37°C Sus scrofa
3.1.1.4 0.00171
-
 syringic acid pH 8.5, 37°C Sus scrofa
3.1.1.4 0.00232
-
 vanillic acid pH 8.5, 37°C Sus scrofa
3.1.1.4 0.00827
-
 aspirin pH 8.5, 37°C Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.4 0.001
-
 pH 8.5, 37°C Sus scrofa gallic acid
3.1.1.4 0.00134
-
 pH 8.5, 37°C Sus scrofa protocatechuic acid
3.1.1.4 0.00181
-
 pH 8.5, 37°C Sus scrofa syringic acid
3.1.1.4 0.00245
-
 pH 8.5, 37°C Sus scrofa vanillic acid
3.1.1.4 0.008742
-
 pH 8.5, 37°C Sus scrofa aspirin

General Information

EC Number General Information Comment Organism
3.1.1.4 physiological function a key enzyme involved in the inflammatory pathway Sus scrofa