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Literature summary extracted from

  • Perez-Gordones, M.C.; Ramirez-Iglesias, J.R.; Cervino, V.; Uzcanga, G.L.; Benaim, G.; Mendoza, M.
    Evidence of the presence of a calmodulin-sensitive plasma membrane Ca2+-ATPase in Trypanosoma equiperdum (2017), Mol. Biochem. Parasitol., 213, 1-11 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.10 Calmodulin
-
 Trypanosoma equiperdum

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.10 Calmidazolium
-
 Trypanosoma equiperdum
7.2.2.10 EGTA
-
 Trypanosoma equiperdum
7.2.2.10 additional information the enzyme is not significantly inhibited by oligomycin Trypanosoma equiperdum
7.2.2.10 sodium orthovanadate
-
 Trypanosoma equiperdum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.2.2.10 0.00018
-
 Ca2+[side 1] in the presence of 0.008 mg/ml calmodulin, at pH 7.2 and 37°C Trypanosoma equiperdum
7.2.2.10 0.00035
-
 Ca2+[side 1] in the absence of calmodulin, at pH 7.2 and 37°C Trypanosoma equiperdum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.10 plasma membrane
-
 Trypanosoma equiperdum 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.10 Ca2+ required Trypanosoma equiperdum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.10 ATP + H2O + Ca2+[side 1] Trypanosoma equiperdum
-
 ADP + phosphate + Ca2+[side 2]
-
 ?
7.2.2.10 ATP + H2O + Ca2+[side 1] Trypanosoma equiperdum Ap-N/D1
-
 ADP + phosphate + Ca2+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.10 Trypanosoma equiperdum A0A1S6KPP9
-
-
7.2.2.10 Trypanosoma equiperdum Ap-N/D1 A0A1S6KPP9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.10 calmodulin-Sepharose column chromatography Trypanosoma equiperdum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.10 ATP + H2O + Ca2+[side 1]
-
 Trypanosoma equiperdum ADP + phosphate + Ca2+[side 2]
-
 ?
7.2.2.10 ATP + H2O + Ca2+[side 1]
-
 Trypanosoma equiperdum Ap-N/D1 ADP + phosphate + Ca2+[side 2]
-
 ?

Subunits

EC Number Subunits Comment Organism
7.2.2.10 ? x * 120000, SDS-PAGE Trypanosoma equiperdum
7.2.2.10 ? x * 118900, calculated from amino acid sequence Trypanosoma equiperdum

Synonyms

EC Number Synonyms Comment Organism
7.2.2.10 plasma membrane Ca2+-ATPase
-
 Trypanosoma equiperdum
7.2.2.10 PMCA
-
 Trypanosoma equiperdum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
7.2.2.10 Trypanosoma equiperdum calculated from amino acid sequence
-
 6.5