Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Han, T.; Li, Y.; Shan, Q.; Liang, W.; Hao, W.; Li, Y.; Tan, X.; Gu, J.
    Characterization of S-adenosylhomocysteine/Methylthioadenosine nucleosidase on secretion of AI-2 and biofilm formation of Escherichia coli (2017), Microb. Pathog., 108, 78-84 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.9 expression in Escherichia coli Escherichia coli
3.2.2.9 expression in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.2.2.9 molecular modeling of structure and docking of inhibitors Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.9 (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-methylpyrrolidin-3-ol most potent inhibitor tested, 5'-deoxyadenosine transition state analogue, dissociation constant of 640 pM. Inhibitor has a weak cell growth effect on Mycobacterium tuberculosis or Mycobacterium smegmatis but is lethal toward Helicobacter pylori Mycobacterium tuberculosis
3.2.2.9 (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol dissociation constant of 87 pM, inhibitor has a weak cell growth effect on Mycobacterium tuberculosis or Mycobacterium smegmatis but is lethal toward Helicobacter pylori Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.2.9 0.00173
-
5'-methylthioadenosine 37°C, pH 7.0 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.9 Escherichia coli P0AF12
-
-
3.2.2.9 Mycobacterium tuberculosis P9WJM3
-
-
3.2.2.9 Mycobacterium tuberculosis H37Rv P9WJM3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.9 5'-deoxyadenosine + H2O
-
Mycobacterium tuberculosis 5-deoxy-D-ribose + adenine
-
?
3.2.2.9 5'-deoxyadenosine + H2O
-
Mycobacterium tuberculosis H37Rv 5-deoxy-D-ribose + adenine
-
?
3.2.2.9 5'-methylthioadenosine + H2O
-
Escherichia coli 5-methylthio-D-ribose + adenine
-
?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.9 MtnN
-
Escherichia coli
3.2.2.9 MtnN
-
Mycobacterium tuberculosis
3.2.2.9 SAHN
-
Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.2.9 0.00000064
-
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-methylpyrrolidin-3-ol pH 7.4, 25°C Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.2.2.9 physiological function deletion of the SAHN gene abolishes the production of the quorum sensing signal AI-2 and biofilm formation Escherichia coli