Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hussein, W.; Feder, D.; Schenk, G.; Guddat, L.; McGeary, R.
    Synthesis and evaluation of novel purple acid phosphatase inhibitors (2019), MedChemComm, 10, 61-71 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.2 1-benzyl-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
3.1.3.2 1-benzyl-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
3.1.3.2 1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
3.1.3.2 1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
3.1.3.2 1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
3.1.3.2 1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
3.1.3.2 1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
3.1.3.2 1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
3.1.3.2 1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
3.1.3.2 1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
3.1.3.2 1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.2 Phaseolus vulgaris
-
-
-
3.1.3.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.2 CM-cellulose column chromatography and Sephadex S-300 gel filtration Phaseolus vulgaris
3.1.3.2 CM-cellulose column chromatography and Sephadex S-300 gel filtration Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Phaseolus vulgaris 4-nitrophenol + phosphate
-
 ?
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Sus scrofa 4-nitrophenol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.2 PAP
-
 Phaseolus vulgaris
3.1.3.2 PAP
-
 Sus scrofa
3.1.3.2 purple acid phosphatase
-
 Phaseolus vulgaris
3.1.3.2 purple acid phosphatase
-
 Sus scrofa
3.1.3.2 tartrate-resistant acid phosphatase
-
 Phaseolus vulgaris
3.1.3.2 tartrate-resistant acid phosphatase
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.2 0.013
-
 1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
3.1.3.2 0.023
-
 1-benzyl-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
3.1.3.2 0.048
-
 1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
3.1.3.2 0.076
-
 1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
3.1.3.2 0.184
-
 1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
3.1.3.2 0.276
-
 1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
3.1.3.2 0.438
-
 1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
3.1.3.2 0.951
-
 1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
3.1.3.2 0.963
-
 1-benzyl-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
3.1.3.2 1.073
-
 1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
3.1.3.2 2.276
-
 1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris