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Literature summary extracted from
- Substrate-inhibitor specificity of cholinesterase and monoamine oxydase from optic ganglia of the pacific squid Todarodes pacificus and commander squid Berryteuthis magister (2017), J. Evol. Biochem. Physiol., 53, 111-122 .
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | (2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate | - |
Berryteuthis magister |  |
| 3.1.1.7 | (2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate | - |
Todarodes pacificus | |
| 3.1.1.7 | (2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium | - |
Berryteuthis magister | |
| 3.1.1.7 | (2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium | - |
Todarodes pacificus | |
| 3.1.1.7 | 2-acetamido-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | 2-acetamido-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | 2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | 2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | 4-acetyl-1,1-dimethylpiperazin-1-ium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | 4-acetyl-1,1-dimethylpiperazin-1-ium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | dipropan-2-yl phosphorofluoridate | - |
Berryteuthis magister | |
| 3.1.1.7 | dipropan-2-yl phosphorofluoridate | - |
Todarodes pacificus | |
| 3.1.1.7 | additional information | organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from erythrocytes, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship | Berryteuthis magister | |
| 3.1.1.7 | additional information | organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from erythrocytes, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship | Todarodes pacificus | |
| 3.1.1.7 | N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | N,N,N-triethylethanaminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | N,N,N-triethylethanaminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | N,N,N-trimethylmethanaminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.7 | N,N,N-trimethylmethanaminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.7 | O,O-diethyl S-hexyl phosphorothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O,O-diethyl S-hexyl phosphorothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | O-ethyl S-heptyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O-ethyl S-heptyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | O-ethyl S-hexyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O-ethyl S-hexyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | O-ethyl S-neopentyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O-ethyl S-neopentyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | O-ethyl S-pentyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | O-ethyl S-pentyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.7 | S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate | - |
Berryteuthis magister | |
| 3.1.1.7 | S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | (2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate | - |
Berryteuthis magister | |
| 3.1.1.8 | (2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate | - |
Todarodes pacificus | |
| 3.1.1.8 | (2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium | - |
Berryteuthis magister | |
| 3.1.1.8 | (2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium | - |
Todarodes pacificus | |
| 3.1.1.8 | 2-acetamido-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | 2-acetamido-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | 2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | 2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | 4-acetyl-1,1-dimethylpiperazin-1-ium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | 4-acetyl-1,1-dimethylpiperazin-1-ium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | dipropan-2-yl phosphorofluoridate | - |
Berryteuthis magister | |
| 3.1.1.8 | dipropan-2-yl phosphorofluoridate | - |
Todarodes pacificus | |
| 3.1.1.8 | additional information | organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from plasma, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship | Berryteuthis magister | |
| 3.1.1.8 | additional information | organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from plasma, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship | Todarodes pacificus | |
| 3.1.1.8 | N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium) | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | N,N,N-triethylethanaminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | N,N,N-triethylethanaminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | N,N,N-trimethylmethanaminium | reversible inhibitor | Berryteuthis magister | |
| 3.1.1.8 | N,N,N-trimethylmethanaminium | reversible inhibitor | Todarodes pacificus | |
| 3.1.1.8 | O,O-diethyl S-hexyl phosphorothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O,O-diethyl S-hexyl phosphorothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | O-ethyl S-heptyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O-ethyl S-heptyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | O-ethyl S-hexyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O-ethyl S-hexyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | O-ethyl S-neopentyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O-ethyl S-neopentyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | O-ethyl S-pentyl methylphosphonothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | O-ethyl S-pentyl methylphosphonothioate | - |
Todarodes pacificus | |
| 3.1.1.8 | S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate | - |
Berryteuthis magister | |
| 3.1.1.8 | S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate | - |
Todarodes pacificus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine + H2O | Todarodes pacificus | - |
choline + acetate | - |
? | |
| 3.1.1.7 | acetylcholine + H2O | Berryteuthis magister | - |
choline + acetate | - |
? | |
| 3.1.1.8 | butyrylcholine + H2O | Todarodes pacificus | - |
choline + butyrate | - |
? | |
| 3.1.1.8 | butyrylcholine + H2O | Berryteuthis magister | - |
choline + butyrate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Berryteuthis magister | - |
different populations from the Central Kuril Islands region, the Olyutor-Navarin region (Bering Sea), and the Prybylovo-Alaska region (Bering Sea) | - |
| 3.1.1.7 | Todarodes pacificus | - |
different populations from autumn and winter | - |
| 3.1.1.8 | Berryteuthis magister | - |
different populations from the Central Kuril Islands region, the Olyutor-Navarin region (Bering Sea), and the Prybylovo-Alaska region (Bering Sea) | - |
| 3.1.1.8 | Todarodes pacificus | - |
different populations from autumn and winter | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | additional information | ChE activity is higher in pacific squid Todarodes pacificus compared to commander squid Berryteuthis magister for the whole substrate series | Todarodes pacificus | - |
| 3.1.1.7 | additional information | ChE activity is higher in pacific squid Todarodes pacificus compared to commander squid Berryteuthis magister for the whole substrate series | Berryteuthis magister | - |
| 3.1.1.7 | optic ganglion | - |
Todarodes pacificus | - |
| 3.1.1.7 | optic ganglion | - |
Berryteuthis magister | - |
| 3.1.1.8 | additional information | ChE activity is higher in pacific squid Todarodes pacificus compared to commander squid Berryteuthis magister for the whole substrate series | Todarodes pacificus | - |
| 3.1.1.8 | additional information | ChE activity is higher in pacific squid Todarodes pacificus compared to commander squid Berryteuthis magister for the whole substrate series | Berryteuthis magister | - |
| 3.1.1.8 | optic ganglion | - |
Todarodes pacificus | - |
| 3.1.1.8 | optic ganglion | - |
Berryteuthis magister | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetyl-beta-methylcholine + H2O | - |
Todarodes pacificus | beta-methylcholine + acetate | - |
? | |
| 3.1.1.7 | acetyl-beta-methylcholine + H2O | - |
Berryteuthis magister | beta-methylcholine + acetate | - |
? | |
| 3.1.1.7 | acetylcholine + H2O | - |
Todarodes pacificus | choline + acetate | - |
? | |
| 3.1.1.7 | acetylcholine + H2O | - |
Berryteuthis magister | choline + acetate | - |
? | |
| 3.1.1.7 | acetylthiocholine + H2O | - |
Todarodes pacificus | thiocholine + acetate | - |
? | |
| 3.1.1.7 | acetylthiocholine + H2O | - |
Berryteuthis magister | thiocholine + acetate | - |
? | |
| 3.1.1.7 | additional information | acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8 | Todarodes pacificus | ? | - |
? | |
| 3.1.1.7 | additional information | acetylcholinesterase also shows activity with butyrylthiocholine, butyrylcholine, and propionylthiocholine, cf. EC 3.1.1.8 | Berryteuthis magister | ? | - |
? | |
| 3.1.1.7 | N-2-acetoxyethyl-N-methylpiperidinium + H2O | - |
Todarodes pacificus | ? | - |
? | |
| 3.1.1.7 | N-2-acetoxyethyl-N-methylpiperidinium + H2O | - |
Berryteuthis magister | ? | - |
? | |
| 3.1.1.8 | butyrylcholine + H2O | - |
Todarodes pacificus | choline + butyrate | - |
? | |
| 3.1.1.8 | butyrylcholine + H2O | - |
Berryteuthis magister | choline + butyrate | - |
? | |
| 3.1.1.8 | butyrylthiocholine + H2O | - |
Todarodes pacificus | thiocholine + butyrate | - |
? | |
| 3.1.1.8 | butyrylthiocholine + H2O | - |
Berryteuthis magister | thiocholine + butyrate | - |
? | |
| 3.1.1.8 | additional information | the cholinesterase also shows activity with acetylthiocholine, and acetylcholine, cf. EC 3.1.1.7 | Todarodes pacificus | ? | - |
? | |
| 3.1.1.8 | additional information | the cholinesterase also shows activity with acetylthiocholine, and acetylcholine, cf. EC 3.1.1.7 | Berryteuthis magister | ? | - |
? | |
| 3.1.1.8 | propionylthiocholine + H2O | - |
Todarodes pacificus | thiocholine + propionate | - |
? | |
| 3.1.1.8 | propionylthiocholine + H2O | - |
Berryteuthis magister | thiocholine + propionate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Todarodes pacificus |
| 3.1.1.7 | AChE | - |
Berryteuthis magister |
| 3.1.1.7 | Acylcholine acylhydrolase | - |
Todarodes pacificus |
| 3.1.1.7 | Acylcholine acylhydrolase | - |
Berryteuthis magister |
| 3.1.1.7 | ChE | - |
Todarodes pacificus |
| 3.1.1.7 | ChE | - |
Berryteuthis magister |
| 3.1.1.7 | More | cf. EC 3.1.1.8 | Todarodes pacificus |
| 3.1.1.7 | More | cf. EC 3.1.1.8 | Berryteuthis magister |
| 3.1.1.8 | Acylcholine acylhydrolase | - |
Todarodes pacificus |
| 3.1.1.8 | Acylcholine acylhydrolase | - |
Berryteuthis magister |
| 3.1.1.8 | BChE | - |
Berryteuthis magister |
| 3.1.1.8 | butyrylcholinesterase | - |
Todarodes pacificus |
| 3.1.1.8 | butyrylcholinesterase | - |
Berryteuthis magister |
| 3.1.1.8 | ChE | - |
Todarodes pacificus |
| 3.1.1.8 | ChE | - |
Berryteuthis magister |
| 3.1.1.8 | More | cf. EC 3.1.1.7 | Todarodes pacificus |
| 3.1.1.8 | More | cf. EC 3.1.1.7 | Berryteuthis magister |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 25 | - |
assay at | Todarodes pacificus |
| 3.1.1.7 | 25 | - |
assay at | Berryteuthis magister |
| 3.1.1.8 | 25 | - |
assay at | Todarodes pacificus |
| 3.1.1.8 | 25 | - |
assay at | Berryteuthis magister |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 7.5 | - |
assay at | Todarodes pacificus |
| 3.1.1.7 | 7.5 | - |
assay at | Berryteuthis magister |
| 3.1.1.8 | 7.5 | - |
assay at | Todarodes pacificus |
| 3.1.1.8 | 7.5 | - |
assay at | Berryteuthis magister |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | additional information | - |
additional information | inhibition kinetics of enzymes from different populations, inhibition type, overview | Todarodes pacificus | |
| 3.1.1.7 | additional information | - |
additional information | inhibition kinetics of enzymes from different populations, inhibition type, overview | Berryteuthis magister | |
| 3.1.1.8 | additional information | - |
additional information | inhibition kinetics of enzymes from different populations, inhibition type, overview | Todarodes pacificus | |
| 3.1.1.8 | additional information | - |
additional information | inhibition kinetics of enzymes from different populations, inhibition type, overview | Berryteuthis magister |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | physiological function | a key enzyme of the cholinergic nervous system | Todarodes pacificus |
| 3.1.1.7 | physiological function | a key enzyme of the cholinergic nervous system | Berryteuthis magister |
| 3.1.1.8 | physiological function | a key enzyme of the cholinergic nervous system | Todarodes pacificus |
| 3.1.1.8 | physiological function | a key enzyme of the cholinergic nervous system | Berryteuthis magister |
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