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Literature summary extracted from

  • Nagappa, L.K.; Satha, P.; Govindaraju, T.; Balaram, H.
    Phosphoglycolate phosphatase is a metabolic proof-reading enzyme essential for cellular function in Plasmodium berghei (2019), J. Biol. Chem., 294, 4997-5007 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.18 NaCl 1 M, shift in oligomeric state of the protein from dimer towards monomer Plasmodium berghei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.18 2.11
-
 Glycerol 2-phosphate pH 7.4, 37°C Plasmodium berghei
3.1.3.18 2.5 3 2-Phosphoglycolate pH 7.4, 37°C Plasmodium berghei
3.1.3.18 4.77
-
 2-phospho-L-lactate pH 7.4, 37°C Plasmodium berghei

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.18 Mg2+ preferred divalent cation Plasmodium berghei
3.1.3.18 additional information divalent cation required Plasmodium berghei

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.18 78000
-
 gel filtration Plasmodium berghei

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.18 Plasmodium berghei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.18 2-phospho-L-lactate + H2O
-
 Plasmodium berghei L-lactate + phosphate
-
 ?
3.1.3.18 2-Phosphoglycolate + H2O
-
 Plasmodium berghei Glycolate + phosphate
-
 ?
3.1.3.18 4-nitrophenyl phosphate + H2O
-
 Plasmodium berghei 4-nitrophenol + phosphate
-
 ?
3.1.3.18 glycerol 2-phosphate + H2O
-
 Plasmodium berghei glycerol + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.18 dimer 2 * 37000, calculated from sequence Plasmodium berghei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.18 10.18
-
 Glycerol 2-phosphate pH 7.4, 37°C Plasmodium berghei
3.1.3.18 67.34
-
 2-phospho-L-lactate pH 7.4, 37°C Plasmodium berghei
3.1.3.18 75.15
-
 2-Phosphoglycolate pH 7.4, 37°C Plasmodium berghei

General Information

EC Number General Information Comment Organism
3.1.3.18 physiological function protein is essential for parasite survival during asexual stages Plasmodium berghei

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.1.3.18 4.83
-
 Glycerol 2-phosphate pH 7.4, 37°C Plasmodium berghei
3.1.3.18 14.11
-
 2-phospho-L-lactate pH 7.4, 37°C Plasmodium berghei
3.1.3.18 29.75
-
 2-Phosphoglycolate pH 7.4, 37°C Plasmodium berghei