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Literature summary extracted from

  • Belardinelli, J.M.; Larrouy-Maumus, G.; Jones, V.; Sorio de Carvalho, L.P.; McNeil, M.R.; Jackson, M.
    Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis (2014), J. Biol. Chem., 289, 27952-27965 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.278 plasma membrane
-
 Mycobacterium tuberculosis 5886
-
2.3.1.279 plasma membrane
-
 Mycobacterium tuberculosis 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.278 a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose Mycobacterium tuberculosis the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
 ?
2.3.1.278 a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose Mycobacterium tuberculosis H37Rv the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
 ?
2.3.1.279 a long-chain-fatty acyl-CoA + alpha,alpha-trehalose Mycobacterium tuberculosis the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains a 2-(long-chain-fatty acyl)-trehalose + CoA
-
 ?
2.3.1.279 a long-chain-fatty acyl-CoA + alpha,alpha-trehalose Mycobacterium tuberculosis H37Rv the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains a 2-(long-chain-fatty acyl)-trehalose + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.278 Mycobacterium tuberculosis P9WIK5
-
-
2.3.1.278 Mycobacterium tuberculosis H37Rv P9WIK5
-
-
2.3.1.279 Mycobacterium tuberculosis P9WIK5
-
-
2.3.1.279 Mycobacterium tuberculosis H37Rv P9WIK5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.278 a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
 ?
2.3.1.278 a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3 Mycobacterium tuberculosis a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
 ?
2.3.1.278 a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis H37Rv a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
 ?
2.3.1.278 a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA-trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3 Mycobacterium tuberculosis H37Rv a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
-
 ?
2.3.1.279 a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis a 2-(long-chain-fatty acyl)-trehalose + CoA
-
 ?
2.3.1.279 a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) Mycobacterium tuberculosis a 2-(long-chain-fatty acyl)-trehalose + CoA
-
 ?
2.3.1.279 a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis H37Rv a 2-(long-chain-fatty acyl)-trehalose + CoA
-
 ?
2.3.1.279 a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) Mycobacterium tuberculosis H37Rv a 2-(long-chain-fatty acyl)-trehalose + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.278 papA3
-
 Mycobacterium tuberculosis
2.3.1.279 papA3
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.278 metabolism the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis
2.3.1.279 metabolism the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis