EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.106 | enzyme isoform MacroD1 is expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.1.1.106 | isoform MacroD1, sitting drop vapor diffusion method, using 0.2 M (NH4)2SO4, 0.1 M HEPES pH 7.5, 25% (w/v) PEG 3350 at 4°C | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.1.106 | C199A | the mutant shows about 90.4% of wild type activity | Homo sapiens |
3.1.1.106 | D122A | the mutant shows about 24.5% of wild type activity | Staphylococcus aureus |
3.1.1.106 | D160A | the mutant shows about 57% of wild type activity | Homo sapiens |
3.1.1.106 | D167A | the mutant shows about 68.7% of wild type activity | Homo sapiens |
3.1.1.106 | D184A | the mutant shows about 39.3% of wild type activity | Homo sapiens |
3.1.1.106 | G124E | the mutant shows about 1.0% of wild type activity | Escherichia coli |
3.1.1.106 | G214E | the mutant shows about 0.2% of wild type activity | Staphylococcus aureus |
3.1.1.106 | G270E | the mutant shows about 1% of wild type activity | Homo sapiens |
3.1.1.106 | H188A | the mutant shows about 57.6% of wild type activity | Homo sapiens |
3.1.1.106 | N171A | the mutant shows about 41.3% of wild type activity | Homo sapiens |
3.1.1.106 | N174A | the mutant shows about 57.3% of wild type activity | Homo sapiens |
3.1.1.106 | N174A/D184A | the mutant shows about 7% of wild type activity | Homo sapiens |
3.1.1.106 | S176A | the mutant shows about 98.4% of wild type activity | Homo sapiens |
3.1.1.106 | S268A | the mutant shows about 77% of wild type activity | Homo sapiens |
3.1.1.106 | T226A | the mutant shows about 102.9% of wild type activity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.106 | ADP-D-ribose | - |
Escherichia coli | |
3.1.1.106 | ADP-D-ribose | - |
Homo sapiens | |
3.1.1.106 | ADP-D-ribose | - |
Staphylococcus aureus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.106 | 0.107 | - |
O-acetyl-ADP-D-ribose | isoform MacroD2, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.27 | - |
O-acetyl-ADP-D-ribose | at pH 7.3 and 23°C | Escherichia coli | |
3.1.1.106 | 0.375 | - |
O-acetyl-ADP-D-ribose | isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 2 | - |
O-acetyl-ADP-D-ribose | at pH 7.3 and 23°C | Staphylococcus aureus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | Staphylococcus aureus | - |
ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | Escherichia coli | - |
ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | Homo sapiens | - |
ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | Staphylococcus aureus | - |
ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | Escherichia coli | - |
ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | Homo sapiens | - |
ADP-D-ribose + acetate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.106 | Escherichia coli | - |
- |
- |
3.1.1.106 | Homo sapiens | A1Z1Q3 | - |
- |
3.1.1.106 | Homo sapiens | Q9BQ69 | - |
- |
3.1.1.106 | Staphylococcus aureus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.1.106 | HisTrap column chromatography and Superdex 75 gel filtration | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.106 | HeLa cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | - |
Staphylococcus aureus | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | - |
Escherichia coli | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 2''-O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | - |
Staphylococcus aureus | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | - |
Escherichia coli | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | 3''-O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | O-acetyl-ADP-D-ribose + H2O | - |
Staphylococcus aureus | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | O-acetyl-ADP-D-ribose + H2O | - |
Escherichia coli | ADP-D-ribose + acetate | - |
? | |
3.1.1.106 | O-acetyl-ADP-D-ribose + H2O | - |
Homo sapiens | ADP-D-ribose + acetate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.106 | MacroD-like protein | - |
Staphylococcus aureus |
3.1.1.106 | MACROD1 | - |
Homo sapiens |
3.1.1.106 | MacroD2 | - |
Homo sapiens |
3.1.1.106 | O-acetyl-ADP-ribose deacetylase | - |
Staphylococcus aureus |
3.1.1.106 | O-acetyl-ADP-ribose deacetylase | - |
Escherichia coli |
3.1.1.106 | O-acetyl-ADP-ribose deacetylase | - |
Homo sapiens |
3.1.1.106 | OAADPr deacetylase | - |
Staphylococcus aureus |
3.1.1.106 | OAADPr deacetylase | - |
Escherichia coli |
3.1.1.106 | OAADPr deacetylase | - |
Homo sapiens |
3.1.1.106 | SAV0325 | - |
Staphylococcus aureus |
3.1.1.106 | ymdB | - |
Escherichia coli |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.106 | 0.002 | - |
O-acetyl-ADP-D-ribose | mutant G270E of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.005 | - |
O-acetyl-ADP-D-ribose | mutant G124E, at pH 7.3 and 23°C | Escherichia coli | |
3.1.1.106 | 0.007 | - |
O-acetyl-ADP-D-ribose | mutant G214E, at pH 7.3 and 23°C | Staphylococcus aureus | |
3.1.1.106 | 0.014 | - |
O-acetyl-ADP-D-ribose | mutant N174A/D184A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.078 | - |
O-acetyl-ADP-D-ribose | mutant D184A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.082 | - |
O-acetyl-ADP-D-ribose | mutant N171A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.113 | - |
O-acetyl-ADP-D-ribose | mutant N174A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.114 | - |
O-acetyl-ADP-D-ribose | mutant D160A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.114 | - |
O-acetyl-ADP-D-ribose | mutant H188A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.12 | - |
O-acetyl-ADP-D-ribose | isoform MacroD2, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.136 | - |
O-acetyl-ADP-D-ribose | mutant D167A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.153 | - |
O-acetyl-ADP-D-ribose | mutant S268A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.179 | - |
O-acetyl-ADP-D-ribose | mutant C199A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.195 | - |
O-acetyl-ADP-D-ribose | mutant S176A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.198 | - |
O-acetyl-ADP-D-ribose | isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.204 | - |
O-acetyl-ADP-D-ribose | mutant T226A of isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 0.48 | - |
O-acetyl-ADP-D-ribose | wild type enzyme, at pH 7.3 and 23°C | Escherichia coli | |
3.1.1.106 | 0.679 | - |
O-acetyl-ADP-D-ribose | mutant D122A, at pH 7.3 and 23°C | Staphylococcus aureus | |
3.1.1.106 | 2.77 | - |
O-acetyl-ADP-D-ribose | wild type enzyme, at pH 7.3 and 23°C | Staphylococcus aureus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.106 | 0.145 | - |
ADP-D-ribose | isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.106 | 0.533 | - |
O-acetyl-ADP-D-ribose | isoform MacroD1, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 1.1 | - |
O-acetyl-ADP-D-ribose | isoform MacroD2, at pH 7.3 and 23°C | Homo sapiens | |
3.1.1.106 | 1.78 | - |
O-acetyl-ADP-D-ribose | at pH 7.3 and 23°C | Escherichia coli | |
3.1.1.106 | 1.84 | - |
O-acetyl-ADP-D-ribose | at pH 7.3 and 23°C | Staphylococcus aureus |