Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Andreoletti, P.; Raas, Q.; Gondcaille, C.; Cherkaoui-Malki, M.; Trompier, D.; Savary, S.
    Predictive structure and topology of peroxisomal ATP-binding cassette (ABC) transporters (2017), Int. J. Mol. Sci., 18, E1593-E1607 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.4 gene ABCD1, sequence comparisons with ABCD2 and ABCD3 Homo sapiens

General Stability

EC Number General Stability Organism
7.6.2.4 dimerization is considered as an obligatory step for stability and function of peroxisomal ABC transporters Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.4 peroxisomal membrane the ABCD transporter contain six transmembrane helices (positions in sequence are analyzed) (TMH) and a membrane peroxisomal targeting signal, direct involvement of this motif in peroxisomal targeting of ABCD3. Peroxisomal targeting of ABCD3 seems to depend on the presence of this motif, the TMH 1 and 2, and also on several residues located in the first 60 amino acids (L21, L22, and L23) and near the TMH 5 (I307-L308). The cytosolic helices form intracellular loops (ICLs), structure overview Homo sapiens 5778
-
7.6.2.4 peroxisomal membrane the ABCD transporter contain six transmembrane helices (positions in sequence are analyzed) and a membrane peroxisomal targeting signal, direct involvement of this motif in peroxisomal targeting of ABCD1. The cytosolic helices form intracellular loops (ICLs), structure overview Homo sapiens 5778
-
7.6.2.4 peroxisomal membrane the ABCD transporter contain six transmembrane helices (positions in sequence are analyzed) and a membrane peroxisomal targeting signal. The cytosolic helices form intracellular loops (ICLs), structure overview Homo sapiens 5778
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.6.2.4 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.4 ATP + H2O + fatty acyl CoA[side 1] Homo sapiens
-
 ADP + phosphate + fatty acyl CoA[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.4 Homo sapiens P28288
-
-
7.6.2.4 Homo sapiens P33897
-
-
7.6.2.4 Homo sapiens Q9UBJ2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.4 ATP + H2O + fatty acyl CoA[side 1]
-
 Homo sapiens ADP + phosphate + fatty acyl CoA[side 2]
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.4 homodimer dimerization is considered as an obligatory step for stability and function of peroxisomal ABC transporters Homo sapiens
7.6.2.4 More structure modeling of ABCD1, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
7.6.2.4 ABCD1
-
 Homo sapiens
7.6.2.4 ABCD4
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
7.6.2.4 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
7.6.2.4 evolution the LLL motif likely belongs to a hydrophobic helix, which is quite well conserved in other ABCD transporters (20-23 in ABCD3). The IL motif near the TMH 5 (I307-L308) belongs to a consensus sequence composed of three hydrophobic residues Homo sapiens
7.6.2.4 evolution the LLL motif likely belongs to a hydrophobic helix, which is quite well conserved in other ABCD transporters (20-36 in ABCD1). The IL motif near the TMH 5 belongs to a consensus sequence composed of three hydrophobic residues [FL]-I-[FL] (LIL in ABCD1) Homo sapiens
7.6.2.4 additional information structure homology modeling using the the 2.85 A resolution rod form structure of ABCB10 (PDB ID 4AYX) as template Homo sapiens
7.6.2.4 additional information structure homology modeling using the the 2.85 A resolution rod form structure of ABCB10 (PDB ID 4AYX) as template, low similarity between ABCB10 and ABCD1 Homo sapiens