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Literature summary extracted from

  • North, B.J.; Verdin, E.
    Sirtuins Sir2-related NAD-dependent protein deacetylases (2004), Genome Biol., 5, 224 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.286 cytoplasm
-
 Homo sapiens 5737
-
2.3.1.286 cytoplasm
-
 Saccharomyces cerevisiae 5737
-
2.3.1.286 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.286 Zn2+ contains zinc Archaeoglobus fulgidus
2.3.1.286 Zn2+ contains zinc Homo sapiens
2.3.1.286 Zn2+ contains zinc Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Archaeoglobus fulgidus overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Homo sapiens overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O Archaeoglobus fulgidus ATCC 49558 overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Archaeoglobus fulgidus O28597
-
-
2.3.1.286 Archaeoglobus fulgidus ATCC 49558 O28597
-
-
2.3.1.286 Homo sapiens Q8IXJ6
-
-
2.3.1.286 Saccharomyces cerevisiae P53686
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 [alpha-tubulin]-N6-acetyl-L-lysine40 + NAD+ + H2O
-
 Homo sapiens [alpha-tubulin]-L-lysine40 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Archaeoglobus fulgidus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Homo sapiens [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
2.3.1.286 [protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Archaeoglobus fulgidus ATCC 49558 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 Hst2p
-
 Saccharomyces cerevisiae
2.3.1.286 Sir2
-
 Archaeoglobus fulgidus
2.3.1.286 Sir2
-
 Homo sapiens
2.3.1.286 Sir2
-
 Saccharomyces cerevisiae
2.3.1.286 SIR2-Af1
-
 Archaeoglobus fulgidus
2.3.1.286 Sir2-Af2
-
 Archaeoglobus fulgidus
2.3.1.286 SIRT2
-
 Homo sapiens
2.3.1.286 sirtuin
-
 Archaeoglobus fulgidus
2.3.1.286 sirtuin
-
 Homo sapiens
2.3.1.286 sirtuin
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.286 NAD+
-
 Archaeoglobus fulgidus
2.3.1.286 NAD+
-
 Homo sapiens
2.3.1.286 NAD+
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.3.1.286 physiological function Sirt2 may act as a tumor suppressor and may function to control the cell cycle by acetylation of alpha-tubulin Homo sapiens