Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liang, G.; Chung, T.; Guo, J.; Zhang, R.; Xü, W.; Tzen, J.; Jiang, R.
    Novel cinobufagin oxime ether derivatives as potential Na+/K+-ATPase inhibitors Synthesis, biological screening and molecular docking (2017), Chem. Res. Chin. Univ., 33, 378-383 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 (3E,5beta,15beta,16beta)-16-(acetyloxy)-3-(hydroxyimino)-8-methyl-14,15-epoxybufa-20,22-dienolide
-
 Sus scrofa
7.2.2.13 (3E,5beta,15beta,16beta)-16-(acetyloxy)-3-(methoxyimino)-8-methyl-14,15-epoxybufa-20,22-dienolide
-
 Sus scrofa
7.2.2.13 (3E,5beta,15beta,16beta)-16-(acetyloxy)-3-[(2-aminoethoxy)imino]-8-methyl-14,15-epoxybufa-20,22-dienolide most potent inhibitor Sus scrofa
7.2.2.13 cinobufagin
-
 Sus scrofa
7.2.2.13 istaroxime
-
 Sus scrofa
7.2.2.13 Ouabain
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.13 membrane
-
 Sus scrofa 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2] Sus scrofa
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.13
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2]
-
 Sus scrofa ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na+/K+-ATPase
-
 Sus scrofa
7.2.2.13 NKA
-
 Sus scrofa
7.2.2.13 sodium pump
-
 Sus scrofa