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Literature summary extracted from

  • Hassan, S.; Ejaz, S.A.; Saeed, A.; Shehzad, M.; Ullah Khan, S.; Lecka, J.; Sevigny, J.; Shabir, G.; Iqbal, J.
    4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity (2018), Bioorg. Chem., 76, 237-248 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 2-chloro-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 2-methyl-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 2-nitro-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 2-phenyl-N-(pyridin-4-yl)acetamide
-
 Homo sapiens
3.1.3.5 3,4,5-trimethoxy-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 3,5-dinitro-N-(pyridine-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 3-chloro-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 3-methyl-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 3-nitro-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 4-chloro-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 4-methyl-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 4-nitro-N-(pyridin-4-yl)benzamide
-
 Homo sapiens
3.1.3.5 N-(pyridin-4-yl)furan-2-carboxamide
-
 Homo sapiens
3.1.3.5 Reactive blue
-
 Homo sapiens
3.1.3.5 Sulfanilic acid
-
 Homo sapiens
3.1.3.5 suramin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.5 a 5'-ribonucleotide + H2O Homo sapiens
-
 a ribonucleoside + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Homo sapiens P21589
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 HeLa cell
-
 Homo sapiens
-
3.1.3.5 K-562 cell
-
 Homo sapiens
-
3.1.3.5 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 a 5'-ribonucleotide + H2O
-
 Homo sapiens a ribonucleoside + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.5 e5'NT
-
 Homo sapiens
3.1.3.5 ecto-5'-nucleotidase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.5 0.00025
-
 pH and temperature not specified in the publication Homo sapiens 3-methyl-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00029
-
 pH and temperature not specified in the publication Homo sapiens 4-chloro-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00038
-
 pH and temperature not specified in the publication Homo sapiens 2-nitro-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00041
-
 pH and temperature not specified in the publication Homo sapiens 2-phenyl-N-(pyridin-4-yl)acetamide
3.1.3.5 0.00042
-
 pH and temperature not specified in the publication Homo sapiens 4-nitro-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00077
-
 pH and temperature not specified in the publication Homo sapiens 2-chloro-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00109
-
 pH and temperature not specified in the publication Homo sapiens 3-nitro-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00171
-
 pH and temperature not specified in the publication Homo sapiens 4-methyl-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00307
-
 pH and temperature not specified in the publication Homo sapiens 3,4,5-trimethoxy-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00411
-
 pH and temperature not specified in the publication Homo sapiens 3-chloro-N-(pyridin-4-yl)benzamide
3.1.3.5 0.00554
-
 pH and temperature not specified in the publication Homo sapiens 3,5-dinitro-N-(pyridine-4-yl)benzamide
3.1.3.5 0.00792
-
 pH and temperature not specified in the publication Homo sapiens N-(pyridin-4-yl)furan-2-carboxamide
3.1.3.5 0.0112
-
 pH and temperature not specified in the publication Homo sapiens 2-methyl-N-(pyridin-4-yl)benzamide
3.1.3.5 0.0421
-
 pH and temperature not specified in the publication Homo sapiens Sulfanilic acid