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Literature summary extracted from

  • Sampaio, L.S.; Iannotti, F.A.; Veneziani, L.; Borelli-Torres, R.T.; De Maio, F.; Piscitelli, F.; Reis, R.A.M.; Di Marzo, V.; Einicker-Lamas, M.
    Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells (2018), Biochem. Pharmacol., 154, 482-491 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 Ouabain specific inhibitor Rattus norvegicus
7.2.2.13 Ouabain specific inhibitor Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.13 basolateral plasma membrane
-
 Rattus norvegicus 16323
-
7.2.2.13 basolateral plasma membrane
-
 Sus scrofa 16323
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2] Rattus norvegicus
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2] Sus scrofa
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Rattus norvegicus
-
-
-
7.2.2.13 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 kidney
-
 Rattus norvegicus
-
7.2.2.13 LLC-PK1 cell
-
 Sus scrofa
-
7.2.2.13 renal proximal tubule cell
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2]
-
 Rattus norvegicus ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2]
-
 Sus scrofa ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Subunits

EC Number Subunits Comment Organism
7.2.2.13 ? x * 110000, SDS-PAGE Rattus norvegicus
7.2.2.13 ? x * 110000, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na+/K+ ATPase
-
 Rattus norvegicus
7.2.2.13 Na+/K+ ATPase
-
 Sus scrofa

Expression

EC Number Organism Comment Expression
7.2.2.13 Rattus norvegicus the enzyme is down-regulated following renal ischemia and reperfusion down
7.2.2.13 Sus scrofa the enzyme is down-regulated following renal ischemia and reperfusion down

General Information

EC Number General Information Comment Organism
7.2.2.13 physiological function main enzyme responsible for Na+ reabsorption through the renal epithelium Rattus norvegicus
7.2.2.13 physiological function main enzyme responsible for Na+ reabsorption through the renal epithelium Sus scrofa