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Literature summary extracted from
- Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis (2015), Antimicrob. Agents Chemother., 59, 1782-1785 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.21.10 | medicine | the absence of RuvA and RuvB orthologues in humans suggests that RuvA and RuvB may serve as potential targets for clinically useful small molecule enhancers of moxifloxacin | Mycobacterium tuberculosis |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.21.10 | wild-type ruvAB from Mycobacterium tuberculosis is cloned into pALACE, and the recombinant plasmid (pALACE-ruvAB) is introduced into strain M136 by electroporation to generate the complemented strain Mycobacterium smegmatis M136C | Mycobacterium tuberculosis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.21.10 | Mycobacterium tuberculosis | P9WGW3 AND P9WGW1 | P9WGW3: RuvA, P9WGW1: RuvB, RuvAB Holliday junction resolvase complex | - |
| 3.1.21.10 | Mycobacterium tuberculosis H37Rv | P9WGW3 AND P9WGW1 | P9WGW3: RuvA, P9WGW1: RuvB, RuvAB Holliday junction resolvase complex | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.21.10 | Holliday junction resolvase | - |
Mycobacterium tuberculosis |
| 3.1.21.10 | RuvAB complex | - |
Mycobacterium tuberculosis |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.21.10 | physiological function | RuvAB-dependent Holliday junction resolution appears to participate in the repair of the DNA fragmentation that initiates the protein synthesis- and ROS-dependent killing pathway | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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