Literature summary extracted from

Velez Edwards, D.R.; Edwards, T.L.; Bray, M.J.; Torstenson, E.; Jones, S.; Shrubsole, M.J.; Muff, H.J.; Hartmann, K.E.
Nonsteroidal anti-inflammatory drug interaction with prostacyclin synthase protects from miscarriage (2017), Sci. Rep., 7, 9874 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.3.99.4	Prostaglandin H2	Homo sapiens	-	Prostaglandin I2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.99.4	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.99.4	Prostaglandin H2	-	Homo sapiens	Prostaglandin I2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.3.99.4	PGI2 synthase	-	Homo sapiens
5.3.99.4	PGIS	-	Homo sapiens
5.3.99.4	prostacyclin synthase	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
5.3.99.4	malfunction	enzyme variant rs5602 is associated with a risk of spontaneous abortion	Homo sapiens

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Release 2023.1 (January 2023)