BRENDA - Enzyme Database show

Nonsteroidal anti-inflammatory drug interaction with prostacyclin synthase protects from miscarriage

Velez Edwards, D.R.; Edwards, T.L.; Bray, M.J.; Torstenson, E.; Jones, S.; Shrubsole, M.J.; Muff, H.J.; Hartmann, K.E.; Sci. Rep. 7, 9874 (2017)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Homo sapiens
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
749359
Homo sapiens
Prostaglandin I2
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Homo sapiens
-
Prostaglandin I2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
749359
Homo sapiens
Prostaglandin I2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
5.3.99.4
malfunction
enzyme variant rs5602 is associated with a risk of spontaneous abortion
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.4
malfunction
enzyme variant rs5602 is associated with a risk of spontaneous abortion
Homo sapiens