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Literature summary extracted from

  • Sasaki, Y.; Ochiai, T.; Takamura, M.; Kondo, Y.; Yokoyama, C.; Hara, S.
    Role of prostacyclin synthase in carcinogenesis (2017), Prostaglandins Other Lipid Mediat., 133, 49-52 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Homo sapiens
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 smooth muscle cell
-
 Homo sapiens
-
5.3.99.4 vascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Homo sapiens Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGI2 synthase
-
 Homo sapiens
5.3.99.4 PGIS
-
 Homo sapiens
5.3.99.4 prostacyclin synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.4 Homo sapiens the enzyme expression is downregulated in several types of cancer down

General Information

EC Number General Information Comment Organism
5.3.99.4 physiological function the enzyme is critical for the regulation of platelet aggregation and vascular tone Homo sapiens