BRENDA - Enzyme Database show

Role of lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth

Kumar, S.; Palaia, T.; Hall, C.; Ragolia, L.; Prostaglandins Other Lipid Mediat. 118-119, 28-33 (2015)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
elevated enzyme levels in the cervicovaginal secretions of women are a potential biomarker for preterm birth
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Mus musculus
-
Prostaglandin D2
-
-
?
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Homo sapiens
P41222
-
-
5.3.99.2
Mus musculus
O09114
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
cervicovaginal fluid
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
749210
Mus musculus
Prostaglandin D2
-
-
-
?
5.3.99.2
Prostaglandin H2
-
749210
Homo sapiens
Prostaglandin D2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
elevated enzyme levels in the cervicovaginal secretions of women are a potential biomarker for preterm birth
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Mus musculus
-
Prostaglandin D2
-
-
?
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
cervicovaginal fluid
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
749210
Mus musculus
Prostaglandin D2
-
-
-
?
5.3.99.2
Prostaglandin H2
-
749210
Homo sapiens
Prostaglandin D2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
5.3.99.2
malfunction
the incidence of preterm birth is significantly reduced to 40% in enzyme-deficient knockout mice
Mus musculus
5.3.99.2
physiological function
the enzyme plays a role in lipopolysaccharide-induced preterm birth
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.2
malfunction
the incidence of preterm birth is significantly reduced to 40% in enzyme-deficient knockout mice
Mus musculus
5.3.99.2
physiological function
the enzyme plays a role in lipopolysaccharide-induced preterm birth
Homo sapiens