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Literature summary extracted from

  • Kumar, S.; Palaia, T.; Hall, C.; Ragolia, L.
    Role of lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth (2015), Prostaglandins Other Lipid Mediat., 118-119, 28-33 .
    View publication on PubMed

Application

EC Number Application Comment Organism
5.3.99.2 medicine elevated enzyme levels in the cervicovaginal secretions of women are a potential biomarker for preterm birth Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.2 Prostaglandin H2 Mus musculus
-
 Prostaglandin D2
-
 ?
5.3.99.2 Prostaglandin H2 Homo sapiens
-
 Prostaglandin D2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Homo sapiens P41222
-
-
5.3.99.2 Mus musculus O09114
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.2 cervicovaginal fluid
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 Prostaglandin H2
-
 Mus musculus Prostaglandin D2
-
 ?
5.3.99.2 Prostaglandin H2
-
 Homo sapiens Prostaglandin D2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 L-PGDS
-
 Mus musculus
5.3.99.2 L-PGDS
-
 Homo sapiens
5.3.99.2 lipocalin-type prostaglandin D2 synthase
-
 Mus musculus
5.3.99.2 lipocalin-type prostaglandin D2 synthase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
5.3.99.2 malfunction the incidence of preterm birth is significantly reduced to 40% in enzyme-deficient knockout mice Mus musculus
5.3.99.2 physiological function the enzyme plays a role in lipopolysaccharide-induced preterm birth Homo sapiens