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Literature summary extracted from
- QM/MM molecular dynamics study of the galactopyranose -> galactofuranose reaction catalysed by Trypanosoma cruzi UDP-galactopyranose mutase (2014), PLoS ONE, 9, e109559 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.4.99.9 | drug development | since the enzyme is not present in mammals, it is a promising target for the design of drugs to treat the Chagas' disease caused by Trypanosoma cruzi in humans | Trypanosoma cruzi |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.9 | UDP-alpha-D-galactopyranose | Trypanosoma cruzi | - |
UDP-alpha-D-galactofuranose | - |
r |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.9 | Trypanosoma cruzi | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 5.4.99.9 | UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose | quantum mechanics-molecular mechanics (QM/MM) molecular dynamics study and reaction mechanism, characterization of the structures of reactants, products, intermediate species and transitions states, overview | Trypanosoma cruzi |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.9 | UDP-alpha-D-galactopyranose | - |
Trypanosoma cruzi | UDP-alpha-D-galactofuranose | - |
r | |
| 5.4.99.9 | UDP-alpha-D-galactopyranose | via iminium ion intermediates | Trypanosoma cruzi | UDP-alpha-D-galactofuranose | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.9 | TcUGM | - |
Trypanosoma cruzi |
| 5.4.99.9 | UGM | - |
Trypanosoma cruzi |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.9 | FAD | involved in the catalyzed reaction, formation of a flavin-substrate/flavin-product adduct | Trypanosoma cruzi | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.4.99.9 | additional information | enzyme TcUGM active site structure, overview | Trypanosoma cruzi |
| 5.4.99.9 | physiological function | the enzyme UDP-galactopyranose mutase (UGM) catalyses the conversion of galactopyranose into galactofuranose. It is critical for the survival and proliferation of several pathogenic agents, both prokaryotic and eukaryotic | Trypanosoma cruzi |
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