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Literature summary extracted from

  • Caballero, Z.C.; Costa-Martins, A.G.; Ferreira, R.C.; P Alves, J.M.; Serrano, M.G.; Camargo, E.P.; Buck, G.A.; Minoprio, P.; G Teixeira, M.M.
    Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences (2015), Parasit. Vectors, 8, 222 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma dionisii
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma cruzi
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma vivax
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma lewisi
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma conorhini
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma serpentis
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma sp. TCC339
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma sp.
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma sp. TCC878
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma cruzi marinkellei
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma erneyi
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma grayi
5.1.1.4 DNA and amino acid sequence determination and analysis, sequence comparisons and sequence comparisons and phylogenetic analysis, genotyping and genetic organization, detailed overview Trypanosoma rangeli

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.4 no activity in Trypanosoma brucei
-
-
-
5.1.1.4 no activity in Trypanosoma congolense
-
-
-
5.1.1.4 Trypanosoma conorhini A0A0F6YF18
-
-
5.1.1.4 Trypanosoma conorhini TCC025 A0A0F6YF18
-
-
5.1.1.4 Trypanosoma cruzi Q4DA80 proline racemase A
-
5.1.1.4 Trypanosoma cruzi Q868H8 proline racemase B
-
5.1.1.4 Trypanosoma cruzi CL Brener Q4DA80 proline racemase A
-
5.1.1.4 Trypanosoma cruzi CL Brener Q868H8 proline racemase B
-
5.1.1.4 Trypanosoma cruzi marinkellei A0A0F6VXD6
-
-
5.1.1.4 Trypanosoma cruzi marinkellei TCC344 A0A0F6VXD6
-
-
5.1.1.4 Trypanosoma dionisii
-
-
-
5.1.1.4 Trypanosoma dionisii TCC211
-
-
-
5.1.1.4 Trypanosoma erneyi A0A0F6VXE2
-
-
5.1.1.4 Trypanosoma erneyi TCC1946 A0A0F6VXE2
-
-
5.1.1.4 Trypanosoma grayi
-
-
-
5.1.1.4 Trypanosoma grayi ANR4
-
-
-
5.1.1.4 Trypanosoma lewisi A0A0F6VXM2
-
-
5.1.1.4 Trypanosoma lewisi TCC034 A0A0F6VXM2
-
-
5.1.1.4 Trypanosoma rangeli
-
-
-
5.1.1.4 Trypanosoma serpentis A0A0F6SCP6
-
-
5.1.1.4 Trypanosoma serpentis TCC1052 A0A0F6SCP6
-
-
5.1.1.4 Trypanosoma sp. A0A0F6VXD9
-
-
5.1.1.4 Trypanosoma sp. TCC1825 / RCF-2014 A0A0F6VXD9
-
-
5.1.1.4 Trypanosoma sp. TCC339 A0A0F6YER1
-
-
5.1.1.4 Trypanosoma sp. TCC878 A0A0F6VXE6
-
-
5.1.1.4 Trypanosoma sp. TCC878 RCF-2014 A0A0F6VXE6
-
-
5.1.1.4 Trypanosoma vivax B8LFE4
-
-
5.1.1.4 Trypanosoma vivax Y486 B8LFE4
-
-

Synonyms

EC Number Synonyms Comment Organism
5.1.1.4 PA45-A
-
 Trypanosoma cruzi
5.1.1.4 PA45-B
-
 Trypanosoma cruzi
5.1.1.4 PRAC
-
 Trypanosoma dionisii
5.1.1.4 PRAC
-
 Trypanosoma cruzi
5.1.1.4 PRAC
-
 Trypanosoma rangeli
5.1.1.4 PRAC
-
 Trypanosoma vivax
5.1.1.4 PRAC
-
 Trypanosoma lewisi
5.1.1.4 PRAC
-
 Trypanosoma conorhini
5.1.1.4 PRAC
-
 Trypanosoma serpentis
5.1.1.4 PRAC
-
 Trypanosoma sp. TCC339
5.1.1.4 PRAC
-
 Trypanosoma sp.
5.1.1.4 PRAC
-
 Trypanosoma sp. TCC878
5.1.1.4 PRAC
-
 Trypanosoma cruzi marinkellei
5.1.1.4 PRAC
-
 Trypanosoma erneyi
5.1.1.4 PRAC
-
 Trypanosoma grayi
5.1.1.4 PRAC1
-
 Trypanosoma vivax
5.1.1.4 proline racemase A
-
 Trypanosoma cruzi
5.1.1.4 proline racemase B
-
 Trypanosoma cruzi
5.1.1.4 TcPRAC
-
 Trypanosoma cruzi
5.1.1.4 Tgr.146.1080 locus name Trypanosoma grayi
5.1.1.4 TryPRAC
-
 Trypanosoma dionisii
5.1.1.4 TryPRAC
-
 Trypanosoma cruzi
5.1.1.4 TryPRAC
-
 Trypanosoma rangeli
5.1.1.4 TryPRAC
-
 Trypanosoma vivax
5.1.1.4 TryPRAC
-
 Trypanosoma lewisi
5.1.1.4 TryPRAC
-
 Trypanosoma conorhini
5.1.1.4 TryPRAC
-
 Trypanosoma serpentis
5.1.1.4 TryPRAC
-
 Trypanosoma sp. TCC339
5.1.1.4 TryPRAC
-
 Trypanosoma sp.
5.1.1.4 TryPRAC
-
 Trypanosoma sp. TCC878
5.1.1.4 TryPRAC
-
 Trypanosoma cruzi marinkellei
5.1.1.4 TryPRAC
-
 Trypanosoma erneyi
5.1.1.4 TryPRAC
-
 Trypanosoma grayi
5.1.1.4 TvPRAC
-
 Trypanosoma vivax

General Information

EC Number General Information Comment Organism
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transfer to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma vivax
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma dionisii
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma cruzi
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma rangeli
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma lewisi
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma conorhini
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma serpentis
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma sp. TCC339
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma sp.
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma sp. TCC878
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma cruzi marinkellei
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma erneyi
5.1.1.4 evolution phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. TryPRAC homologues as single copy genes per haploid genome in 12 of 15 Trypanosoma species, including Trypanosoma cruzi and Trypanosoma cruzi marinkellei, Trypanosoma dionisii, Trypanosoma erneyi, Trypanosoma rangeli, Trypanosoma conorhini and Trypanosoma lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes match Trypanosoma cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and TcIII, respectively. PRAC homologues are identified in trypanosomes from anurans, snakes, crocodiles, lizards, and birds. Most trypanosomes have intact PRAC genes. Trypanosoma rangeli possesses only pseudogenes, maybe in the process of being lost. Trypanosoma brucei, Trypanosoma congolense and their allied species, except the more distantly related Trypanosoma vivax, have completely lost PRAC genes. The genealogy of TryPRAC homologs supports an evolutionary history congruent with the Trypanosoma phylogeny Trypanosoma grayi