Literature summary extracted from

Son, D.J.; Akiba, S.; Hong, J.T.; Yun, Y.P.; Hwang, S.Y.; Park, Y.H.; Lee, S.E.
Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response (2014), Nutrients, 6, 3336-3352 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.3.99.5	imidazole	-	Oryctolagus cuniculus
5.3.99.5	piperine	significant inhibition at 0.3 mM	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.3.99.5	prostaglandin H2	Oryctolagus cuniculus	-	thromboxane A2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.99.5	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
5.3.99.5	blood platelet	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.99.5	prostaglandin H2	-	Oryctolagus cuniculus	thromboxane A2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.3.99.5	thromboxane A2 synthase	-	Oryctolagus cuniculus
5.3.99.5	TXA2 synthase	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)