Literature summary extracted from
Hikita, K.; Yamada, S.; Shibata, R.; Katoh, M.; Murata, T.; Kato, K.; Tanaka, H.; Kaneda, N.
Inhibitory effect of isoflavones from Erythrina poeppigiana on the growth of HL-60 human leukemia cells through inhibition of glyoxalase I (2015), Nat. Prod. Commun., 10, 1581-1584 .
Application
EC Number |
Application |
Comment |
Organism |
---|
4.4.1.5 |
medicine |
treatment of HL-60 cells leads to significant accumulation of substrate methylglyoxal and the caspase 3 activity of the cell lysate increases. Compound shows anti-proliferative activity against HL-60 cells |
Homo sapiens |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
4.4.1.5 |
isolupalbigenin |
treatment of HL-60 cells leads to significant accumulation of substrate methylglyoxal and the caspase 3 activity of the cell lysate increases. Compound shows anti-proliferative activity against HL-60 cells |
Homo sapiens |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.4.1.5 |
Homo sapiens |
Q04760 |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
4.4.1.5 |
glutathione + methylglyoxal |
- |
Homo sapiens |
(R)-S-lactoylglutathione |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
4.4.1.5 |
Glo1 |
- |
Homo sapiens |