EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | cinaciguat | cinaciguat activates the heme-free enzyme in a concentration-dependent manner with an EC50 value of about 0.2 microM and maximal cGMP formation at 10 microM. The compound causes time- and concentration-dependent relaxation of precontracted vessels with a maximal effect observed at 90 minutes. The dilatory response is not affected by extensive washout of the drug. Cinaciguat-induced vasodilation is associated with a time- and concentration-dependent increase of cGMP levels. The effect of cinaciguat on 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one-oxidized (ferric) soluble guanylate cyclase is moderate, reaching about 10%-15% of maximal activity | Sus scrofa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.2 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.2 | artery | coronary artery | Sus scrofa | - |