BRENDA - Enzyme Database show

Comprehensive evaluation of the binding of lipocalin-type prostaglandin D synthase to poorly water-soluble drugs

Teraoka, Y.; Kume, S.; Lin, Y.; Atsuji, S.; Inui, T.; Mol. Pharm. 14, 3558-3567 (2017)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
5.3.99.2
C65A/C167A
inactive
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
atovaquone
-
Homo sapiens
5.3.99.2
imatinib
-
Homo sapiens
5.3.99.2
lapatinib
-
Homo sapiens
5.3.99.2
nilotinib
-
Homo sapiens
5.3.99.2
telmisartan
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Homo sapiens
P41222
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.3.99.2
glutathione Sepharose column chromatography and Superdex 75 gel filtration
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
748694
Homo sapiens
Prostaglandin D2
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
5.3.99.2
C65A/C167A
inactive
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
atovaquone
-
Homo sapiens
5.3.99.2
imatinib
-
Homo sapiens
5.3.99.2
lapatinib
-
Homo sapiens
5.3.99.2
nilotinib
-
Homo sapiens
5.3.99.2
telmisartan
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.2
glutathione Sepharose column chromatography and Superdex 75 gel filtration
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
748694
Homo sapiens
Prostaglandin D2
-
-
-
?