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Literature summary extracted from

  • Tao, L.; Cheng, Q.
    Novel beta-carotene ketolases from non-photosynthetic bacteria for canthaxanthin synthesis (2004), Mol. Genet. Genomics, 272, 530-537 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.63 expression of DR0093 in the Escherichia coli strain that accumulates beta-carotene results in a carotenoid mixture containing 32% canthaxanthin and 27% echinenone Deinococcus radiodurans
1.14.99.63 expression of the beta-carotene ketolase gene in an Escherichia coli strain which accumulates beta-carotene results in the production of canthaxanthin Rhodococcus erythropolis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2 Rhodococcus erythropolis
-
 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2 Deinococcus radiodurans
-
 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2 Rhodococcus erythropolis AN12
-
 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2 Deinococcus radiodurans R1
-
 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2 Rhodococcus erythropolis
-
 canthaxanthin + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2 Deinococcus radiodurans
-
 canthaxanthin + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2 Rhodococcus erythropolis AN12
-
 canthaxanthin + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2 Deinococcus radiodurans R1
-
 canthaxanthin + 2 acceptor + 3 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.63 Deinococcus radiodurans Q9RY57
-
-
1.14.99.63 Deinococcus radiodurans R1 Q9RY57
-
-
1.14.99.63 Rhodococcus erythropolis Q5IKE4
-
-
1.14.99.63 Rhodococcus erythropolis AN12 Q5IKE4
-
-
2.5.1.29 Rhodococcus erythropolis Q5IKE3
-
-
2.5.1.29 Rhodococcus erythropolis ATCC 47072 Q5IKE3
-
-
2.5.1.32 Rhodococcus erythropolis Q5IKE1
-
-
2.5.1.32 Rhodococcus erythropolis ATCC 47072 Q5IKE1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2
-
 Rhodococcus erythropolis echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2
-
 Deinococcus radiodurans echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2
-
 Rhodococcus erythropolis AN12 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 beta-carotene + 2 reduced acceptor + 2 O2
-
 Deinococcus radiodurans R1 echinenone + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2
-
 Rhodococcus erythropolis canthaxanthin + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2
-
 Deinococcus radiodurans canthaxanthin + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2
-
 Rhodococcus erythropolis AN12 canthaxanthin + 2 acceptor + 3 H2O
-
 ?
1.14.99.63 echinenone + 2 reduced acceptor + 2 O2
-
 Deinococcus radiodurans R1 canthaxanthin + 2 acceptor + 3 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.63 beta-carotene ketolase
-
 Rhodococcus erythropolis
1.14.99.63 beta-carotene ketolase
-
 Deinococcus radiodurans
1.14.99.63 CrtO
-
 Rhodococcus erythropolis
1.14.99.63 CrtO ketolase
-
 Rhodococcus erythropolis
1.14.99.63 DR0093
-
 Deinococcus radiodurans
2.5.1.29 CrtE
-
 Rhodococcus erythropolis
2.5.1.29 geranylgeranyl pyrophosphate synthase
-
 Rhodococcus erythropolis
2.5.1.29 GGPP synthase
-
 Rhodococcus erythropolis
2.5.1.32 CrtB
-
 Rhodococcus erythropolis
2.5.1.32 phytoene synthase
-
 Rhodococcus erythropolis

General Information

EC Number General Information Comment Organism
1.14.99.63 metabolism involved in carotenoid synthesis Rhodococcus erythropolis
1.14.99.63 metabolism involved in carotenoid synthesis Deinococcus radiodurans
2.5.1.29 malfunction crtE knockout mutants are white, in contrast to the light orange color of the wild-type strains Rhodococcus erythropolis