EC Number | Cloned (Comment) | Organism |
---|---|---|
5.3.99.2 | expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.2 | 11-hydroxy-DELTA9-tetrahydrocannabinol | - |
Homo sapiens | |
5.3.99.2 | 11-nor-9-carboxy-DELTA9-tetrahydrocannabinol | - |
Homo sapiens | |
5.3.99.2 | ajulemic acid | - |
Homo sapiens | |
5.3.99.2 | cannabidiol | - |
Homo sapiens | |
5.3.99.2 | DELTA9-tetrahydrocannabinol | - |
Homo sapiens | |
5.3.99.2 | additional information | not inhibited by oleamide, palmitoylethanolamide, oleoylethanolamide, prostamide F2alpha, N-arachidonoylethanolamine/anandamide, and 2-arachidonoylglycerol | Homo sapiens | |
5.3.99.2 | oleic acid | - |
Homo sapiens | |
5.3.99.2 | palmitoleic acid | - |
Homo sapiens | |
5.3.99.2 | prostaglandin E2 | - |
Homo sapiens | |
5.3.99.2 | prostaglandin E2-glyceryl ester | - |
Homo sapiens | |
5.3.99.2 | prostaglandin F2alpha | - |
Homo sapiens | |
5.3.99.2 | SBFI-26 | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.2 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin D2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.2 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.2 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin D2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.2 | L-PGDS | - |
Homo sapiens |
5.3.99.2 | lipocalin-type prostaglandin d synthase | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.3.99.2 | 0.0018 | - |
oleic acid | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.0022 | - |
ajulemic acid | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.003 | - |
SBFI-26 | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.0037 | - |
palmitoleic acid | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.0078 | - |
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.0112 | - |
prostaglandin E2-glyceryl ester | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.061 | - |
11-hydroxy-DELTA9-tetrahydrocannabinol | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.0779 | - |
cannabidiol | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.081 | - |
prostaglandin F2alpha | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.128 | - |
prostaglandin E2 | at pH 7.6 and 25°C | Homo sapiens | |
5.3.99.2 | 0.175 | - |
DELTA9-tetrahydrocannabinol | at pH 7.6 and 25°C | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.3.99.2 | physiological function | the enzyme has dual functional roles as a prostaglandin D2-synthesizing enzyme and as an extracellular transporter for diverse lipophilic compounds in the cerebrospinal fluid | Homo sapiens |