BRENDA - Enzyme Database show

Lipocalin-type prostaglandin D synthase is a novel phytocannabinoid-binding protein

Elmes, M.W.; Volpe, A.D.; d'Oelsnitz, S.; Sweeney, J.M.; Kaczocha, M.; Lipids 53, 353-360 (2018)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
11-hydroxy-DELTA9-tetrahydrocannabinol
-
Homo sapiens
5.3.99.2
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol
-
Homo sapiens
5.3.99.2
ajulemic acid
-
Homo sapiens
5.3.99.2
cannabidiol
-
Homo sapiens
5.3.99.2
DELTA9-tetrahydrocannabinol
-
Homo sapiens
5.3.99.2
additional information
not inhibited by oleamide, palmitoylethanolamide, oleoylethanolamide, prostamide F2alpha, N-arachidonoylethanolamine/anandamide, and 2-arachidonoylglycerol
Homo sapiens
5.3.99.2
oleic acid
-
Homo sapiens
5.3.99.2
palmitoleic acid
-
Homo sapiens
5.3.99.2
prostaglandin E2
-
Homo sapiens
5.3.99.2
prostaglandin E2-glyceryl ester
-
Homo sapiens
5.3.99.2
prostaglandin F2alpha
-
Homo sapiens
5.3.99.2
SBFI-26
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
748520
Homo sapiens
Prostaglandin D2
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
5.3.99.2
0.0018
-
oleic acid
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0022
-
ajulemic acid
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.003
-
SBFI-26
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0037
-
palmitoleic acid
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0078
-
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0112
-
prostaglandin E2-glyceryl ester
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.061
-
11-hydroxy-DELTA9-tetrahydrocannabinol
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0779
-
cannabidiol
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.081
-
prostaglandin F2alpha
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.128
-
prostaglandin E2
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.175
-
DELTA9-tetrahydrocannabinol
at pH 7.6 and 25C
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
11-hydroxy-DELTA9-tetrahydrocannabinol
-
Homo sapiens
5.3.99.2
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol
-
Homo sapiens
5.3.99.2
ajulemic acid
-
Homo sapiens
5.3.99.2
cannabidiol
-
Homo sapiens
5.3.99.2
DELTA9-tetrahydrocannabinol
-
Homo sapiens
5.3.99.2
additional information
not inhibited by oleamide, palmitoylethanolamide, oleoylethanolamide, prostamide F2alpha, N-arachidonoylethanolamine/anandamide, and 2-arachidonoylglycerol
Homo sapiens
5.3.99.2
oleic acid
-
Homo sapiens
5.3.99.2
palmitoleic acid
-
Homo sapiens
5.3.99.2
prostaglandin E2
-
Homo sapiens
5.3.99.2
prostaglandin E2-glyceryl ester
-
Homo sapiens
5.3.99.2
prostaglandin F2alpha
-
Homo sapiens
5.3.99.2
SBFI-26
-
Homo sapiens
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
5.3.99.2
0.0018
-
oleic acid
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0022
-
ajulemic acid
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.003
-
SBFI-26
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0037
-
palmitoleic acid
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0078
-
11-nor-9-carboxy-DELTA9-tetrahydrocannabinol
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0112
-
prostaglandin E2-glyceryl ester
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.061
-
11-hydroxy-DELTA9-tetrahydrocannabinol
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.0779
-
cannabidiol
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.081
-
prostaglandin F2alpha
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.128
-
prostaglandin E2
at pH 7.6 and 25C
Homo sapiens
5.3.99.2
0.175
-
DELTA9-tetrahydrocannabinol
at pH 7.6 and 25C
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
748520
Homo sapiens
Prostaglandin D2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
5.3.99.2
physiological function
the enzyme has dual functional roles as a prostaglandin D2-synthesizing enzyme and as an extracellular transporter for diverse lipophilic compounds in the cerebrospinal fluid
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.2
physiological function
the enzyme has dual functional roles as a prostaglandin D2-synthesizing enzyme and as an extracellular transporter for diverse lipophilic compounds in the cerebrospinal fluid
Homo sapiens