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Literature summary extracted from

  • Omori, K.; Morikawa, T.; Kunita, A.; Nakamura, T.; Aritake, K.; Urade, Y.; Fukayama, M.; Murata, T.
    Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells (2018), J. Pathol., 244, 84-96 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.2 Prostaglandin H2 Mus musculus
-
 Prostaglandin D2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.2 B16-F1 cell
-
 Mus musculus
-
5.3.99.2 endothelial cell
-
 Mus musculus
-
5.3.99.2 Lewis lung carcinoma cell
-
 Mus musculus
-
5.3.99.2 melanoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 Prostaglandin H2
-
 Mus musculus Prostaglandin D2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 L-PGDS
-
 Mus musculus
5.3.99.2 lipocalin-type prostaglandin d synthase
-
 Mus musculus
5.3.99.2 PTGDS
-
 Mus musculus

General Information

EC Number General Information Comment Organism
5.3.99.2 malfunction enzyme deficiency accelerates the growth of melanoma in mice. Enzyme deficiency results in functional changes of tumor endothelial cells such as accelerated vascular hyperpermeability, angiogenesis, and endothelial-to-mesenchymal transition in tumors, which in turn reduce tumor cell apoptosis Mus musculus