Any feedback?
Literature summary extracted from
- In silico docking and molecular dynamics simulation of 3-dehydroquinate synthase (DHQS) from Mycobacterium tuberculosis (2018), J. Mol. Model., 24, 132 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.4 | ZINC04113772 | - |
Mycobacterium tuberculosis |  |
| 4.2.3.4 | ZINC08983432 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC11881196 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC12243261 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC12455413 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC14743064 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC14882944 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC14986690 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC18122756 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC19334122 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC20136483 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC20779557 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC633887 | - |
Mycobacterium tuberculosis | |
| 4.2.3.4 | ZINC633895 | - |
Mycobacterium tuberculosis | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.3.4 | Co2+ | activates | Mycobacterium tuberculosis | |
| 4.2.3.4 | Zn2+ | activates | Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.4 | 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | Mycobacterium tuberculosis | - |
3-dehydroquinate + phosphate | - |
? | |
| 4.2.3.4 | 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | Mycobacterium tuberculosis H37Rv | - |
3-dehydroquinate + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.3.4 | Mycobacterium tuberculosis | P9WPX9 | - |
- |
| 4.2.3.4 | Mycobacterium tuberculosis H37Rv | P9WPX9 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.3.4 | 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | - |
Mycobacterium tuberculosis | 3-dehydroquinate + phosphate | - |
? | |
| 4.2.3.4 | 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | - |
Mycobacterium tuberculosis H37Rv | 3-dehydroquinate + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.3.4 | DHQS | - |
Mycobacterium tuberculosis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
