Literature summary extracted from

Raj, D.; Mu, J.; Jiang, H.; Kabat, J.; Singh, S.; Sullivan, M.; Fay, M.; McCutchan, T.; Su, X.
Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione (2009), J. Biol. Chem., 284, 7687-7696 .

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
7.6.2.3	membrane	-	Plasmodium falciparum	16020	-
7.6.2.3	vesicle	-	Plasmodium falciparum	31982	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.6.2.3	Plasmodium falciparum	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
7.6.2.3	gametocyte	-	Plasmodium falciparum	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.6.2.3	ATP + H2O + amodiaquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + amodiaquine[side 2]	-	?
7.6.2.3	ATP + H2O + artemisinin[side 1]	-	Plasmodium falciparum	ADP + phosphate + artemisinin[side 2]	-	?
7.6.2.3	ATP + H2O + chloroquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + chloroquine[side 2]	-	?
7.6.2.3	ATP + H2O + glutathione[side 1]	-	Plasmodium falciparum	ADP + phosphate + glutathione[side 2]	-	?
7.6.2.3	ATP + H2O + mefloquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + mefloquine[side 2]	-	?
7.6.2.3	ATP + H2O + piperaquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + piperaquine[side 2]	-	?
7.6.2.3	ATP + H2O + primaquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + primaquine[side 2]	-	?
7.6.2.3	ATP + H2O + proguanil[side 1]	-	Plasmodium falciparum	ADP + phosphate + proguanil[side 2]	-	?
7.6.2.3	ATP + H2O + quinine[side 1]	-	Plasmodium falciparum	ADP + phosphate + quinine[side 2]	-	?

Subunits

EC Number	Subunits	Comment	Organism
7.6.2.3	?	x * 214000, SDS-PAGE	Plasmodium falciparum

Synonyms

EC Number	Synonyms	Comment	Organism
7.6.2.3	MRP	-	Plasmodium falciparum
7.6.2.3	multidrug resistance-associated protein	-	Plasmodium falciparum
7.6.2.3	Pgh-1	-	Plasmodium falciparum

General Information

EC Number	General Information	Comment	Organism
7.6.2.3	physiological function	the enzyme plays a role in the efflux of glutathione or glutathione conjugates as well as chloroquine and quinine, and contributes to parasite responses to multiple antimalarial drugs by pumping drugs outside the parasite	Plasmodium falciparum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)