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Literature summary extracted from

  • Philmus, B.; Decamps, L.; Berteau, O.; Begley, T.
    Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis (2015), J. Am. Chem. Soc., 137, 5406-5413 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.147 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine Methanocaldococcus jannaschii the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
?
2.5.1.147 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine Methanocaldococcus jannaschii DSM 2661 the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
?
4.3.1.32 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine Methanocaldococcus jannaschii the enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of the redox cofactor coenzyme F420 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
-
?
4.3.1.32 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine Methanocaldococcus jannaschii DSM 2661 the enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of the redox cofactor coenzyme F420 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.147 Methanocaldococcus jannaschii Q58826
-
-
2.5.1.147 Methanocaldococcus jannaschii DSM 2661 Q58826
-
-
4.3.1.32 Methanocaldococcus jannaschii Q57888
-
-
4.3.1.32 Methanocaldococcus jannaschii DSM 2661 Q57888
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.147 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
-
Methanocaldococcus jannaschii 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
?
2.5.1.147 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420 Methanocaldococcus jannaschii 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
?
2.5.1.147 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
-
Methanocaldococcus jannaschii DSM 2661 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
?
2.5.1.147 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420 Methanocaldococcus jannaschii DSM 2661 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
?
4.3.1.32 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine
-
Methanocaldococcus jannaschii 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
-
?
4.3.1.32 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine the enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of the redox cofactor coenzyme F420 Methanocaldococcus jannaschii 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
-
?
4.3.1.32 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine
-
Methanocaldococcus jannaschii DSM 2661 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
-
?
4.3.1.32 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine the enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of the redox cofactor coenzyme F420 Methanocaldococcus jannaschii DSM 2661 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.147 cofH
-
Methanocaldococcus jannaschii
2.5.1.147 MjCofH
-
Methanocaldococcus jannaschii
4.3.1.32 cofG
-
Methanocaldococcus jannaschii
4.3.1.32 MjCofG
-
Methanocaldococcus jannaschii

General Information

EC Number General Information Comment Organism
2.5.1.147 metabolism the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420 Methanocaldococcus jannaschii
4.3.1.32 metabolism the enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of the redox cofactor coenzyme F420 Methanocaldococcus jannaschii