BRENDA - Enzyme Database show

ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1

Arana, M.R.; Altenberg, G.; Curr. Med. Chem. 25, 1-17 (2017)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.2
plasma membrane
-
Homo sapiens
5886
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
7.6.2.2
Homo sapiens
Q2M3G0
-
-
7.6.2.2
Homo sapiens
Q8HXQ5
-
-
7.6.2.2
Homo sapiens
Q9UNQ0
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.2
enterocyte
BCRP
Homo sapiens
-
7.6.2.2
hepatocyte
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.2
ATP + H2O + acridine orange[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + acridine orange[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + aflatoxin B[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + aflatoxin B[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + amiodarone[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + amiodarone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + arsenite[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + arsenite[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azidopine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + azidopine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + bilirubin[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + bilirubin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calcein[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + calcein[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calphostin C[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + calphostin C[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + clorambucil[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + clorambucil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + colchicine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + colchicine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclophosphamide[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + cyclophosphamide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclosporine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + cyclosporine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + daunorubicin[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + daunorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + daunorubicin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + daunorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + dehydroepiandrosterone sulfate[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + dehydroepiandrosterone sulfate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + dinitrophenyl[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + dinitrophenyl[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + dipyridamol[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + dipyridamol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + doxorubicin[side 1]
substrate for P-glycoprotein, BCRP, and MRP1
747619
Homo sapiens
ADP + phosphate + doxorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + erythromycin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + erythromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + estradiol[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + estradiol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + estrone-3-sulfate[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + estrone-3-sulfate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + estrone[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + estrone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ethacrynic acid[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + ethacrynic acid[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + etoposide[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + etoposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + FK-506[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + FK-506[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + folic acid[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + folic acid[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gefitinib[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + gefitinib[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + genistein[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + genistein[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + genistein[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + genistein[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + glutathione disulfide[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + glutathione disulfide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + hematoporphyrin[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + hematoporphyrin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + indinavir[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + indinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leucovorin[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + leucovorin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leukotriene C4[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + leukotriene C4[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leukotriene D4[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + leukotriene D4[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + melphalan[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + melphalan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + methotrexate[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + methotrexate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitomycin C[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + mitomycin C[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitoxantrone[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + mitoxantrone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + progesterone[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + progesterone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + prostaglandin E2[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + prostaglandin E2[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + PSC-833[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + PSC-833[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quercetin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + quercetin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quinidine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + quinidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rapamycin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + rapamycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rhodamine 123[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + rhodamine 123[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + riboflavin[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + riboflavin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ritonavir[side 1]
substrate for P-glycoprotein and MRP1
747619
Homo sapiens
ADP + phosphate + ritonavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + staurosporine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + staurosporine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tamoxifen[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + tamoxifen[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + taxol[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + taxol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + teniposide[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + teniposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + verapamil[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + verapamil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vinblastine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + vinblastine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vincristine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + vincristine[side 2]
-
-
-
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.2
plasma membrane
-
Homo sapiens
5886
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.2
enterocyte
BCRP
Homo sapiens
-
7.6.2.2
hepatocyte
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.2
ATP + H2O + acridine orange[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + acridine orange[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + aflatoxin B[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + aflatoxin B[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + amiodarone[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + amiodarone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + arsenite[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + arsenite[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azidopine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + azidopine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + bilirubin[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + bilirubin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calcein[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + calcein[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calphostin C[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + calphostin C[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + clorambucil[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + clorambucil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + colchicine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + colchicine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclophosphamide[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + cyclophosphamide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclosporine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + cyclosporine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + daunorubicin[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + daunorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + daunorubicin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + daunorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + dehydroepiandrosterone sulfate[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + dehydroepiandrosterone sulfate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + dinitrophenyl[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + dinitrophenyl[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + dipyridamol[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + dipyridamol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + doxorubicin[side 1]
substrate for P-glycoprotein, BCRP, and MRP1
747619
Homo sapiens
ADP + phosphate + doxorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + erythromycin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + erythromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + estradiol[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + estradiol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + estrone-3-sulfate[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + estrone-3-sulfate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + estrone[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + estrone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ethacrynic acid[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + ethacrynic acid[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + etoposide[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + etoposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + FK-506[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + FK-506[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + folic acid[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + folic acid[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gefitinib[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + gefitinib[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + genistein[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + genistein[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + genistein[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + genistein[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + glutathione disulfide[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + glutathione disulfide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + hematoporphyrin[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + hematoporphyrin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + indinavir[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + indinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leucovorin[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + leucovorin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leukotriene C4[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + leukotriene C4[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leukotriene D4[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + leukotriene D4[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + melphalan[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + melphalan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + methotrexate[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + methotrexate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitomycin C[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + mitomycin C[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitoxantrone[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + mitoxantrone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + progesterone[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + progesterone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + prostaglandin E2[side 1]
substrate for MRP1
747619
Homo sapiens
ADP + phosphate + prostaglandin E2[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + PSC-833[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + PSC-833[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quercetin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + quercetin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quinidine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + quinidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rapamycin[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + rapamycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rhodamine 123[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + rhodamine 123[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + riboflavin[side 1]
substrate for BCRP
747619
Homo sapiens
ADP + phosphate + riboflavin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ritonavir[side 1]
substrate for P-glycoprotein and MRP1
747619
Homo sapiens
ADP + phosphate + ritonavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + staurosporine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + staurosporine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tamoxifen[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + tamoxifen[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + taxol[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + taxol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + teniposide[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + teniposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + verapamil[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + verapamil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vinblastine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + vinblastine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vincristine[side 1]
substrate for P-glycoprotein
747619
Homo sapiens
ADP + phosphate + vincristine[side 2]
-
-
-
?